Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Stem cell-based therapy has drawn attention for enhancing the osseointegration efficiency
after joint replacement in the rheumatoid arthritis (RA). However, therapeutic efficacy of this …

Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular
damage, functional loss, and comorbidity. The development of effective biologics and small …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), are complex chronic inflammatory conditions of the gastrointestinal tract that are driven …

Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate
tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic …

Rheumatoid arthritis (RA) is an autoimmune disease that severely affects patients' physical
and mental health, leading to chronic synovitis and destruction of bone joints. Although …

Rheumatoid arthritis (RA) is a chronic systemic, autoimmune and inflammatory disease
represented as synovitis, pannus formation, adjacent bone erosions, and joint destruction …