The podocyte as a target for therapies—new and old

PW Mathieson - Nature Reviews Nephrology, 2012 - nature.com
Injury to the podocyte results in proteinuria and often leads to progressive kidney disease.
As podocytes have limited ability to repair and/or regenerate, the extent of podocyte injury is …

Mesenchymal stem cells in kidney inflammation and repair

AF Wise, SD Ricardo - Nephrology, 2012 - Wiley Online Library
Mesenchymal stem cells are a heterogeneous population of fibroblast‐like stromal cells that
have been isolated from the bone marrow and a number of organs and tissues including the …

Mesenchymal stem cells, not conditioned medium, contribute to kidney repair after ischemia-reperfusion injury

L Xing, R Cui, L Peng, J Ma, X Chen, RJ Xie… - Stem cell research & …, 2014 - Springer
Introduction Studies have shown that stem cells exert their therapeutic effects on acute
kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in …

Stem cells in kidney ischemia: from inflammation and fibrosis to renal tissue regeneration

R Cianci, M Simeoni, E Cianci, O De Marco… - International Journal of …, 2023 - mdpi.com
Ischemic nephropathy consists of progressive renal function loss due to renal hypoxia,
inflammation, microvascular rarefaction, and fibrosis. We provide a literature review focused …

Endometrial mesenchymal stem cells isolated from menstrual blood by adherence

X Du, Q Yuan, Y Qu, Y Zhou, J Bei - Stem Cells International, 2016 - Wiley Online Library
Objective. To find a convenient and efficient way to isolate MSCs from human menstrual
blood and to investigate their biological characteristics, proliferative capacity, and secretion …

Type VIII collagen modulates TGF-β1-induced proliferation of mesangial cells

I Loeffler, U Hopfer, D Koczan… - Journal of the American …, 2011 - journals.lww.com
Mesangial cells in diabetic mice and human kidneys with diabetic nephropathy exhibit
increased type VIII collagen, a nonfibrillar protein that exists as a heterodimer composed of …

Enhancing the therapeutic potential of mesenchymal stromal cell-based therapies with an anti-fibrotic agent for the treatment of chronic kidney disease

Y Li, SD Ricardo, CS Samuel - International Journal of Molecular …, 2022 - mdpi.com
Chronic kidney disease (CKD) affects 1 in 10 members of the general population, placing
these patients at an increasingly high risk of kidney failure. Despite the significant burden of …

Update on the podocyte

PW Mathieson - Current opinion in nephrology and hypertension, 2009 - journals.lww.com
Drugs that have beneficial effects on podocytes can improve our ability to treat important
renal diseases, including diabetic nephropathy. Currently available agents can be …

Kidney repair and stem cells: a complex and controversial process

BA Yeagy, S Cherqui - Pediatric nephrology, 2011 - Springer
Over the last decade, stem cells have been the topic of much debate and investigation for
their regenerative potential in the case of renal injury. This review focuses on bone marrow …

The use of stem cells in kidney disease

P Chhabra, KL Brayman - Current opinion in organ …, 2009 - journals.lww.com
The use of stem cells in kidney disease : Current Opinion in Organ Transplantation The use of
stem cells in kidney disease : Current Opinion in Organ Transplantation Log in or Register …