The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

Planar polarity describes the coordinated polarisation of cells or structures in the plane of a
tissue. The patterning mechanisms that underlie planar polarity are well characterised in …

It is fundamentally important that signaling gradients provide positional information to govern
morphogenesis of multicellular organisms. Morphogen gradients can generate different cell …

Satellite cells in skeletal muscle are a heterogeneous population of stem cells and
committed progenitors. We found that quiescent satellite stem cells expressed the Wnt …

Most, if not all, cell types and tissues display several aspects of polarization. In addition to
the ubiquitous epithelial cell polarity along the apical-basolateral axis, many epithelial …

Neural tube defects (NTDs) are common, severe congenital malformations whose causation
involves multiple genes and environmental factors. Although more than 200 genes are …

The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds
240, including 205 representing specific genes, 30 for unidentified genes, and 9 …

Background Airway cilia must be physically oriented along the longitudinal tissue axis for
concerted, directional motility that is essential for proper mucociliary clearance. Results We …

In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …