Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by
all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as …

The 18kD translocator protein (TSPO) is used as a positron emission tomography (PET)
target to quantify neuroinflammation in patients. In Alzheimer's disease (AD), the cerebellum …

Translocase of outer mitochondrial membrane 40 (TOMM40) is located in the outer
membrane of mitochondria. TOMM40 is essential for protein import into mitochondria …

Liposomes modified with tetradecyltriphenylphosphonium bromide with dual loading of α-
tocopherol and donepezil hydrochloride were successfully designed for intranasal …

Neurodegenerative diseases are a complex problem affecting millions of people around the
world. The pathogenesis is not fully understood, but it is known that both insufficiency of the …

Neuroinflammation plays a crucial role in the onset and the progression of several
neuropathologies, from neurodegenerative disorders to migraine, from Rett syndrome to …

Cardiovascular disease (CVD), involving the pathological alteration of the heart or blood
vessels, is one of the main causes of disability and death worldwide, with an estimated 18.6 …

This review highlights the complex role of fatty acid β-oxidation in brain metabolism. It
demonstrates the fundamental importance of fatty acid degradation as a fuel in energy …

During aging, several tissues and biological systems undergo a progressive decline in
function, leading to age-associated diseases such as neurodegenerative, inflammatory …