Molecular Subtypes as a Basis for Stratified Use of Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer—A Narrative Review

G Sjödahl, J Abrahamsson, C Bernardo, P Eriksson… - Cancers, 2022 - mdpi.com
Simple Summary Although it is one disease, cancer of the urinary bladder occurs in several
molecular subtypes that can be identified by laboratory tests. Tumors of advanced stages …

Management of muscle-invasive bladder cancer in the 2020s: challenges and perspectives

G Gakis - European Urology Focus, 2020 - Elsevier
Despite an increased use of neoadjuvant and adjuvant chemotherapy, the long-term
survival rates after radical cystectomy or trimodal therapy (TMT) for muscle-invasive bladder …

The future of perioperative therapy in advanced renal cell carcinoma: how can we PROSPER?

HD Patel, M Puligandla, BM Shuch, BC Leibovich… - Future …, 2019 - Future Medicine
Patients with high-risk renal cell carcinoma (RCC) experience high rates of recurrence
despite definitive surgical resection. Recent trials of adjuvant tyrosine kinase inhibitor …

Radiomics-based model for predicting pathological complete response to neoadjuvant chemotherapy in muscle-invasive bladder cancer

SJ Choi, KJ Park, C Heo, BW Park, M Kim, JK Kim - Clinical radiology, 2021 - Elsevier
AIM To develop and validate a radiomics-based model for predicting response to
neoadjuvant chemotherapy (NAC) using baseline computed tomography (CT) images in …

[HTML][HTML] The safety, tolerability, and efficacy of a neoadjuvant gemcitabine intravesical drug delivery system (TAR-200) in muscle-invasive bladder cancer patients: a …

S Daneshmand, ISG Brummelhuis, KS Pohar… - … Oncology: Seminars and …, 2022 - Elsevier
Objectives Neoadjuvant chemotherapy and radical cystectomy (RC) are underutilized
standards of care for the treatment of muscle-invasive bladder cancer (MIBC) due to high …

Survival and oncologic outcomes of complete transurethral resection of bladder tumor prior to neoadjuvant chemotherapy for muscle-invasive bladder cancer

JS Pak, CR Haas, CB Anderson, GJ DeCastro… - … Oncology: Seminars and …, 2021 - Elsevier
Objectives Prior studies have shown that pathologic complete response at radical
cystectomy, a significant prognostic factor, can be attributed to both neoadjuvant …

Four versus 3 cycles of neoadjuvant chemotherapy for muscle-invasive bladder cancer: implications for pathological response and survival

HD Patel, SH Patel, E Blanco-Martinez… - The Journal of …, 2022 - auajournals.org
Purpose: The ideal number of neoadjuvant chemotherapy (NAC) cycles for muscle-invasive
bladder cancer is uncertain with 3 to 4 representing the standard of care (SOC). We …

Urothelial carcinoma: update on staging and reporting, and pathologic changes following neoadjuvant chemotherapies

M Aron, M Zhou - Surgical Pathology Clinics, 2022 - surgpath.theclinics.com
Staging and reporting of cancers of the urinary tract have undergone major changes in the
past decade to meet the needs for improved patient management. Substantial progress has …

Impact of maximal transurethral resection on pathological outcomes at cystectomy in a large, multi-institutional cohort

PS Kirk, Y Lotan, H Zargar, AS Fairey… - The Journal of …, 2023 - auajournals.org
Purpose: While the presence of residual disease at the time of radical cystectomy for bladder
cancer is an established prognostic indicator, controversy remains regarding the importance …

Multicenter validation of histopathologic tumor regression grade after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma

CS Voskuilen, HZ Oo, V Genitsch, LA Smit… - The American journal …, 2019 - journals.lww.com
Response classification after neoadjuvant chemotherapy in muscle-invasive bladder
carcinoma is based on the TNM stage at radical cystectomy. We recently showed that …