Renin–angiotensin–aldosterone system inhibitors and risk of Covid-19

HR Reynolds, S Adhikari, C Pulgarin… - … England Journal of …, 2020 - Mass Medical Soc
Background There is concern about the potential of an increased risk related to medications
that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus …

Spontaneous Coronary Artery Dissection: JACC State-of-the-Art Review

SN Hayes, MS Tweet, D Adlam, ESH Kim… - Journal of the American …, 2020 - jacc.org
Over the past decade, spontaneous coronary artery dissection (SCAD) has emerged as an
important cause of myocardial infarction, particularly among younger women. The pace of …

[HTML][HTML] Apolipoprotein B and cardiovascular disease: biomarker and potential therapeutic target

J Behbodikhah, S Ahmed, A Elyasi, LJ Kasselman… - Metabolites, 2021 - mdpi.com
Apolipoprotein (apo) B, the critical structural protein of the atherogenic lipoproteins, has two
major isoforms: apoB48 and apoB100. ApoB48 is found in chylomicrons and chylomicron …

[HTML][HTML] Oxidative stress in cardiovascular diseases: still a therapeutic target?

T Senoner, W Dichtl - Nutrients, 2019 - mdpi.com
Cardiovascular diseases (CVD) are complex entities with heterogenous pathophysiologic
mechanisms and increased oxidative stress has been viewed as one of the potential …

[HTML][HTML] Global epidemiology and future trends of heart failure

G Lippi, F Sanchis-Gomar - AME medical journal, 2020 - amj.amegroups.org
Some population statistics suggested that the epidemiologic burden of heart failure (HF)
may have significantly decreased between 2000 and 2010. However, this trend could not be …

Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease

A Abbate, S Toldo, C Marchetti, J Kron… - Circulation …, 2020 - Am Heart Assoc
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

[HTML][HTML] Cardiovascular risks associated with gender and aging

JL Rodgers, J Jones, SI Bolleddu… - Journal of …, 2019 - mdpi.com
The aging and elderly population are particularly susceptible to cardiovascular disease. Age
is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are …

[HTML][HTML] Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

D Zhu, Z Li, K Huang, TG Caranasos, JS Rossi… - Nature …, 2021 - nature.com
Cardiac patches are an effective way to deliver therapeutics to the heart. However, such
procedures are normally invasive and difficult to perform. Here, we develop and test a …

[HTML][HTML] Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of …

K Dorjee, H Kim, E Bonomo, R Dolma - PloS one, 2020 - journals.plos.org
Introduction Progression of COVID-19 to severe disease and death is insufficiently
understood. Objective Summarize the prevalence of risk factors and adverse outcomes and …

[HTML][HTML] Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair

WP Lafuse, DJ Wozniak, MVS Rajaram - Cells, 2020 - mdpi.com
The immune system plays a pivotal role in the initiation, development and resolution of
inflammation following insult or damage to organs. The heart is a vital organ which supplies …