The “neuro-glial-vascular” unit: the role of glia in neurovascular unit formation and dysfunction

EC Kugler, J Greenwood… - Frontiers in Cell and …, 2021 - frontiersin.org
The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …

Revisiting the role of neurotransmitters in epilepsy: An updated review

E Akyuz, AK Polat, E Eroglu, I Kullu, E Angelopoulou… - Life sciences, 2021 - Elsevier
Epilepsy is a neurologicaldisorder characterized by persistent predisposition to recurrent
seizurescaused by abnormal neuronal activity in the brain. Epileptic seizures maydevelop …

Immune dysregulation in autism spectrum disorder: what do we know about it?

MA Robinson-Agramonte, E Noris García… - International journal of …, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental
disorders characterized by a wide and variable set of neuropsychiatric symptoms, including …

Astrocytes as a target for therapeutic strategies in epilepsy: current insights

N Çarçak, F Onat, E Sitnikova - Frontiers in molecular neuroscience, 2023 - frontiersin.org
Astrocytes are specialized non-neuronal glial cells of the central nervous system,
contributing to neuronal excitability and synaptic transmission (gliotransmission). Astrocytes …

Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

Y Xiong, J Chen, Y Li - Frontiers in Neuroscience, 2023 - frontiersin.org
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with onset in
childhood. The mechanisms underlying ASD are unclear. In recent years, the role of …

GABA release from astrocytes in health and disease

W Kilb, S Kirischuk - International Journal of Molecular Sciences, 2022 - mdpi.com
Astrocytes are the most abundant glial cells in the central nervous system (CNS) mediating a
variety of homeostatic functions, such as spatial K+ buffering or neurotransmitter reuptake. In …

Emerging role of neuron‐glia in neurological disorders: at a glance

MM Rahman, MR Islam, M Yamin… - Oxidative medicine …, 2022 - Wiley Online Library
Based on the diverse physiological influence, the impact of glial cells has become much
more evident on neurological illnesses, resulting in the origins of many diseases appearing …

Role of oligodendrocytes and myelin in the pathophysiology of autism spectrum disorder

AY Galvez-Contreras, D Zarate-Lopez… - Brain sciences, 2020 - mdpi.com
Autism Spectrum Disorder (ASD) is an early neurodevelopmental disorder that involves
deficits in interpersonal communication, social interaction, and repetitive behaviors …

Microglial Activation and Oxidative Stress in PM2.5-Induced Neurodegenerative Disorders

J Song, K Han, Y Wang, R Qu, Y Liu, S Wang, Y Wang… - Antioxidants, 2022 - mdpi.com
Fine particulate matter (PM2. 5) pollution remains a prominent environmental problem
worldwide, posing great threats to human health. The adverse effects of PM2. 5 on the …

Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury

W Czyżewski, M Mazurek, L Sakwa, M Szymoniuk… - Cells, 2024 - mdpi.com
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced
therapeutic interventions. This detailed review explores the critical roles of astrocytes, key …