Prokineticin receptor 2 (PROKR2) encodes for a G-protein-coupled receptor that can bind
PROK1 and PROK2. Mice lacking Prokr2 have been shown to present abnormal olfactory …

Neurons that secrete gonadotropin-releasing hormone (GnRH) drive vertebrate
reproduction. Genetic lesions that disrupt these neurons in humans lead to congenital …

Gonadotropin-releasing hormone (GnRH) deficiency (GD) is a disorder characterized by
absent or delayed puberty, with largely unknown genetic causes. The purpose of this study …

Innervation of the hypothalamic median eminence by Gonadotropin-Releasing Hormone
(GnRH) neurons is vital to ensure puberty onset and successful reproduction. However, the …

Gonadotropin-releasing hormone (GnRH) neurons are key neuroendocrine cells in the brain
as they control reproduction by regulating hypothalamic-pituitary-gonadal axis function. In …

ABSTRACT Fibroblast growth factor 8 (FGF8), acting through the fibroblast growth factor
receptor 1 (FGFR1), has an important role in the development of gonadotropin-releasing …

In vertebrates, the embryonic olfactory epithelium contains progenitors that will give rise to
distinct classes of neurons, including olfactory sensory neurons (OSNs; involved in odor …

Chemosensory cues are vital for social and sexual behaviours and are primarily detected
and processed by the vomeronasal system (VNS), whose plastic capacity has been …

Abstract Background/Objectives This study aims to elucidate the genetic causes of
congenital hypogonadotropic hypogonadism (CHH), a rare genetic disorder resulting in …

STUDY QUESTION What is the contribution of genetic defects in Portuguese patients with
congenital hypogonadotropic hypogonadism (CHH)? SUMMARY ANSWER Approximately …