Disorders of chondrocyte differentiation and endochondral osteogenesis are major
underlying factors in skeletal developmental disorders, including tibial dysplasia (TD) …

Polymeric biomaterials have emerged as a highly promising candidate for drug delivery
systems (DDS), exhibiting significant potential to enhance the therapeutic landscape of …

ABSTRACT Context• Osteoarthritis (OA) is a high-incidence, chronic condition, with an
extremely high prevalence among older adults. OA seriously compromises the normal living …

Degenerative musculoskeletal disorders are a group of age-related diseases of the
locomotive system that severely affects the patient's ability to work and cause adverse …

Pain disorders are the primary cause of disability nowadays. These disorders, such as
rheumatoid arthritis (RA) and osteoarthritis (OA), cause loss of function, joint pain and …

Background: Alpinia officinarum Hance (AOH) has a long history in China as a Chinese
medicine and exerts the pharmacological effects of antidiabetic and gastrointestinal …

Osteoarthritis (OA) causes pain and disability in the elderly and has placed a severe burden
on healthcare worldwide. Excessive death and decreased density of chondrocytes are …

This study aimed to investigate the role of KLF5 (Kruppel-like factor 5) in the abnormal
dedifferentiation of chondrocytes (CHs) observed in osteoarthritis (OA) and monolayer …

The experiment involved thirty male rats divided into six groups. One group received saline
as a control, another received monosodium iodoacetate (MIA) to induce OA, and the …

Osteoarthritis (OA) is a debilitating joint disorder characterized by progressive cartilage
degeneration, leading to pain and impaired mobility. Conventional OA treatments have …