Castration-resistant prostate cancer (CRPC), especially metastatic castration-resistant
prostate cancer (mCRPC) is one of the most prevalent malignancies and main cause of …

The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …

Phenotypic plasticity–the ability of an individual organism to alter its features in direct
response to a change in its environment–is ubiquitous. Understanding how and why this …

Background Plastic responses of plants to the environment are ubiquitous. Phenotypic
plasticity occurs in many forms and at many biological scales, and its adaptive value …

This paper presents the Adaptive Calibration Model (ACM), an evolutionary–developmental
theory of individual differences in the functioning of the stress response system. The stress …

Over the past decade, advances in both molecular developmental biology and evolutionary
ecology have made possible a new understanding of organisms as dynamic systems …

Phenotypic plasticity (the ability of a single genotype to produce multiple phenotypes in
response to variation in the environment) is commonplace. Yet its evolutionary significance …

Phenotypic plasticity can serve as a stepping stone towards adaptation. Recently, studies
have shown that gene expression contributes to emergent stress responses such as thermal …

Developmental plasticity describes situations where a specific input during an individual's
development produces a lasting alteration in phenotype. Some instances of developmental …

This theme issue pursues an exploration of the potential of taking into account the
environmental sensitivity of development to explaining the evolution of metazoan life cycles …