DNA fragmentation is an important factor in the aetiology of male infertility. However, it is still
underevaluated and its inclusion in routine semen analysis is debated. DNA fragmentation …

Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two
types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of …

The purpose of this ASRM Practice Committee report is to provide clinicians with principles
and strategies for the evaluation of couples with male infertility problems. This revised …

Chromosome abnormalities have been known for over 50 years, though the methods of
analysis have become increasing more sophisticated and precise. Surprisingly, the …

Unexplained male infertility is a diagnosis reserved for men in whom routine semen
analyses results are within normal values and physical as well as endocrine abnormalities …

BACKGROUND: The integrity of sperm DNA is important for the success of natural or
assisted fertilization, as well as normal development of the embryo, fetus and child. ICSI, by …

Highlights•Sperm nuclear and chromatin abnormalities are common among infertile men
and are known to influence natural reproduction.•The haploid paternal genome provides the …

Sperm pathology is presented as the discipline of characterizing structural and functional
deficiencies in abnormal spermatozoa. This concept complements that of sperm morphology …

The first edition of the Textbook of Assisted Reproductive Techniques was published in
2001. As the textbook now enters its sixth edition, some 45 years since the birth of Louise …

This chapter is an update to our previous reviews on this subject. 1, 2 In those reviews we
explained that when an in vitro fertilization (IVF) clinic successfully attains a high …