The E factor at 30: a passion for pollution prevention

RA Sheldon - Green Chemistry, 2023 - pubs.rsc.org
The introduction of the E Factor in 1992 focussed attention on the problem of waste
generation, defined as everything but the desired product, in chemicals manufacture and …

From protein film electrochemistry to nanoconfined enzyme cascades and the electrochemical leaf

FA Armstrong, B Cheng, RA Herold… - Chemical …, 2022 - ACS Publications
Protein film electrochemistry (PFE) has given unrivalled insight into the properties of redox
proteins and many electron-transferring enzymes, allowing investigations of otherwise ill …

Large-scale amidations in process chemistry: practical considerations for reagent selection and reaction execution

J Magano - Organic Process Research & Development, 2022 - ACS Publications
This review describes the practical aspects involved in the implementation of large-scale
amidations in process chemistry. Coupling reagent, base, additive, and solvent selections …

Streamlining design, engineering, and applications of enzymes for sustainable biocatalysis

RA Sheldon, D Brady - ACS Sustainable Chemistry & Engineering, 2021 - ACS Publications
In this Perspective we show how an expansion of the scope and impact of biocatalysis in
industrial organic synthesis is enabled by streamlining the underpinning biocatalyst and …

Engineering enzyme properties for improved biocatalytic processes in batch and continuous flow

RA Rocha, RE Speight, C Scott - Organic Process Research & …, 2022 - ACS Publications
The widespread adoption of biocatalysis by industry to perform highly selective chemical
syntheses has been made possible only by the development of highly effective methods in …

Biocatalysis: A smart and green tool for the preparation of chiral drugs

G Rossino, MS Robescu, E Licastro, C Tedesco… - Chirality, 2022 - Wiley Online Library
Over the last decades, biocatalysis has achieved growing interest thanks to its potential to
enable high efficiency, high yield, and eco‐friendly processes aimed at the production of …

Efficient Production of L‐Homophenylalanine by Enzymatic‐Chemical Cascade Catalysis

D Gao, W Song, J Wu, L Guo, C Gao… - Angewandte Chemie …, 2022 - Wiley Online Library
Abstract L‐Homophenylalanine (L‐HPA) is a vital building block for the synthesis of
numerous chiral drugs. However, the high cost of starting materials limits the industrial …

Recent advances in biocatalysis for drug synthesis

A Kinner, P Nerke, R Siedentop, T Steinmetz… - Biomedicines, 2022 - mdpi.com
Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …

Supramolecular ionic liquid gels for enzyme entrapment

HT Imam, K Hill, A Reid, S Mix, PC Marr… - ACS Sustainable …, 2023 - ACS Publications
Reported herein is an entrapment method for enzyme immobilization that does not require
the formation of new covalent bonds. Ionic liquid supramolecular gels are formed containing …

Applications of ionic liquids in whole-cell and isolated enzyme biocatalysis

HT Imam, V Krasňan, M Rebroš, AC Marr - Molecules, 2021 - mdpi.com
Ionic liquids have unique chemical properties that have fascinated scientists in many fields.
The effects of adding ionic liquids to biocatalysts are many and varied. The uses of ionic …