The E factor at 30: a passion for pollution prevention
RA Sheldon - Green Chemistry, 2023 - pubs.rsc.org
The introduction of the E Factor in 1992 focussed attention on the problem of waste
generation, defined as everything but the desired product, in chemicals manufacture and …
generation, defined as everything but the desired product, in chemicals manufacture and …
From protein film electrochemistry to nanoconfined enzyme cascades and the electrochemical leaf
Protein film electrochemistry (PFE) has given unrivalled insight into the properties of redox
proteins and many electron-transferring enzymes, allowing investigations of otherwise ill …
proteins and many electron-transferring enzymes, allowing investigations of otherwise ill …
Large-scale amidations in process chemistry: practical considerations for reagent selection and reaction execution
J Magano - Organic Process Research & Development, 2022 - ACS Publications
This review describes the practical aspects involved in the implementation of large-scale
amidations in process chemistry. Coupling reagent, base, additive, and solvent selections …
amidations in process chemistry. Coupling reagent, base, additive, and solvent selections …
Streamlining design, engineering, and applications of enzymes for sustainable biocatalysis
RA Sheldon, D Brady - ACS Sustainable Chemistry & Engineering, 2021 - ACS Publications
In this Perspective we show how an expansion of the scope and impact of biocatalysis in
industrial organic synthesis is enabled by streamlining the underpinning biocatalyst and …
industrial organic synthesis is enabled by streamlining the underpinning biocatalyst and …
Engineering enzyme properties for improved biocatalytic processes in batch and continuous flow
RA Rocha, RE Speight, C Scott - Organic Process Research & …, 2022 - ACS Publications
The widespread adoption of biocatalysis by industry to perform highly selective chemical
syntheses has been made possible only by the development of highly effective methods in …
syntheses has been made possible only by the development of highly effective methods in …
Biocatalysis: A smart and green tool for the preparation of chiral drugs
G Rossino, MS Robescu, E Licastro, C Tedesco… - Chirality, 2022 - Wiley Online Library
Over the last decades, biocatalysis has achieved growing interest thanks to its potential to
enable high efficiency, high yield, and eco‐friendly processes aimed at the production of …
enable high efficiency, high yield, and eco‐friendly processes aimed at the production of …
Efficient Production of L‐Homophenylalanine by Enzymatic‐Chemical Cascade Catalysis
Abstract L‐Homophenylalanine (L‐HPA) is a vital building block for the synthesis of
numerous chiral drugs. However, the high cost of starting materials limits the industrial …
numerous chiral drugs. However, the high cost of starting materials limits the industrial …
Recent advances in biocatalysis for drug synthesis
A Kinner, P Nerke, R Siedentop, T Steinmetz… - Biomedicines, 2022 - mdpi.com
Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …
Supramolecular ionic liquid gels for enzyme entrapment
Reported herein is an entrapment method for enzyme immobilization that does not require
the formation of new covalent bonds. Ionic liquid supramolecular gels are formed containing …
the formation of new covalent bonds. Ionic liquid supramolecular gels are formed containing …
Applications of ionic liquids in whole-cell and isolated enzyme biocatalysis
HT Imam, V Krasňan, M Rebroš, AC Marr - Molecules, 2021 - mdpi.com
Ionic liquids have unique chemical properties that have fascinated scientists in many fields.
The effects of adding ionic liquids to biocatalysts are many and varied. The uses of ionic …
The effects of adding ionic liquids to biocatalysts are many and varied. The uses of ionic …