Accumulating evidence shows that hallmarks of cancer include:“genetic and epigenetic
alterations leading to inactivation of cancer suppressors, overexpression of oncogenes …

Folate-pathway gene polymorphisms have been implicated in several cancers and
investigated inconclusively in relation to prostate cancer. We conducted a systematic review …

DNA methylation is an epigenetic mechanism that regulates gene transcription without
changing primary nucleotide sequences. In mammals, DNA methylation involves the …

Prostate cancer is the second most common cancer and the second leading cause of cancer
death in men. However, prostate cancer can be effectively treated and cured, if it is …

It is tempting to assume that a gradual accumulation of damage 'causes' an organism to age,
but other biological processes present during the lifespan, whether 'programmed'or …

Background The prostate gland is the most common site of cancer and the second leading
cause of cancer mortality in American men. It is well known that epigenetic alterations such …

One of the major obstacles in the treatment of hormone-refractory prostate cancer (HRPC) is
the development of chemoresistant tumors. The aim of this study is to evaluate the role of …

Baicalein is a Chinese herbal compound extracted from Scutellaria baicalensis that has anti-
tumor properties. The aim of this study was to elucidate the mechanisms of action of …

BACKGROUND Epigenetic modifications play a key role in the in prostate cancer (Pca)
progression to a hormone refractory state (HRPC) and the current use of agents targeting …

Background: DNA methylation is an important mechanism for gene silencing and has
already been described for several genes in breast cancer. A previous …