Differentiation of diabetes by pathophysiology, natural history, and prognosis

JS Skyler, GL Bakris, E Bonifacio, T Darsow… - Diabetes, 2017 - Am Diabetes Assoc
The American Diabetes Association, JDRF, the European Association for the Study of
Diabetes, and the American Association of Clinical Endocrinologists convened a research …

[HTML][HTML] Classification and diagnosis of diabetes

SM Genuth, JP Palmer, DM Nathan - 2021 - europepmc.org
The classification of diabetes was originally limited to only two categories called juvenile-
onset diabetes mellitus, now known as type 1 diabetes mellitus, and adult-onset diabetes …

A type 1 diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk

MJ Redondo, S Geyer, AK Steck, S Sharp… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to
predict progression of islet autoimmunity and T1D in at-risk individuals. RESEARCH …

Reduction of circulating neutrophils precedes and accompanies type 1 diabetes

A Valle, GM Giamporcaro, M Scavini, A Stabilini… - Diabetes, 2013 - Am Diabetes Assoc
Human type 1 diabetes (T1D) is an autoimmune disease associated with major
histocompatibility complex polymorphisms, β-cell autoantibodies, and autoreactive T cells …

The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients

JM Sosenko, JS Skyler, JP Palmer, JP Krischer… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE We assessed whether a risk score that incorporates levels of multiple islet
autoantibodies could enhance the prediction of type 1 diabetes (T1D). RESEARCH DESIGN …

Established and emerging biomarkers for the prediction of type 1 diabetes: a systematic review

RA Watkins, C Evans-Molina, JS Blum… - Translational …, 2014 - Elsevier
Type 1 diabetes (T1D) is an autoimmune disease with a prolonged and variable latent
period that culminates in the destruction of pancreatic β-cells and the development of …

OGTT Metrics Surpass Continuous Glucose Monitoring Data for T1D Prediction in Multiple-Autoantibody–Positive Individuals

A Ylescupidez, C Speake… - The Journal of …, 2024 - academic.oup.com
Context The value of continuous glucose monitoring (CGM) for monitoring autoantibody
(AAB)-positive individuals in clinical trials for progression of type 1 diabetes (T1D) is …

Index60 identifies individuals at appreciable risk for stage 3 among an autoantibody-positive population with normal 2-hour glucose levels: implications for current …

BM Nathan, MJ Redondo, H Ismail, L Jacobsen… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE We assessed whether Index60, a composite measure of fasting C-peptide, 60-
min C-peptide, and 60-min glucose, could improve the metabolic staging of type 1 diabetes …

[HTML][HTML] Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials

TP Staeva, L Chatenoud, R Insel, MA Atkinson - Diabetes, 2013 - ncbi.nlm.nih.gov
Type 1 diabetes (T1D) results from the immune system's misguided attack on insulin-
producing pancreatic β-cells, leading to lifelong insulin replacement therapy as well as to …

Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies

L Yu, DC Boulware, CA Beam, JC Hutton… - Diabetes …, 2012 - Am Diabetes Assoc
OBJECTIVE We assessed diabetes risk associated with zinc transporter-8 antibodies
(ZnT8A), islet cell antibodies (ICA), and HLA type and age in relatives of people with type 1 …