Not just amyloid: physiological functions of the amyloid precursor protein family

UC Müller, T Deller, M Korte - Nature Reviews Neuroscience, 2017 - nature.com
Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

[HTML][HTML] How does hormesis impact biology, toxicology, and medicine?

EJ Calabrese, MP Mattson - NPJ aging and mechanisms of disease, 2017 - nature.com
Hormesis refers to adaptive responses of biological systems to moderate environmental or
self-imposed challenges through which the system improves its functionality and/or …

The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease

N Lonnemann, S Hosseini… - Proceedings of the …, 2020 - National Acad Sciences
Numerous studies demonstrate that neuroinflammation is a key player in the progression of
Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore …

Genes and environments, development and time

WT Boyce, MB Sokolowski… - Proceedings of the …, 2020 - National Acad Sciences
A now substantial body of science implicates a dynamic interplay between genetic and
environmental variation in the development of individual differences in behavior and health …

The impact of the digital revolution on human brain and behavior: where do we stand?

M Korte - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
This overview will outline the current results of neuroscience research on the possible
effects of digital media use on the human brain, cognition, and behavior. This is of …

Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function

S Hosseini, E Wilk, K Michaelsen-Preusse… - Journal of …, 2018 - Soc Neuroscience
Acute influenza infection has been reported to be associated with neurological symptoms.
However, the long-term consequences of an infection with neurotropic and non-neurotropic …

Emulation of synaptic functions with low voltage organic memtransistor for hardware oriented neuromorphic computing

S Sagar, K Udaya Mohanan, S Cho, LA Majewski… - Scientific reports, 2022 - nature.com
Here, various synaptic functions and neural network simulation based pattern-recognition
using novel, solution-processed organic memtransistors (mem Ts) with an unconventional …

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial

M Wirth, G Benson, C Schwarz, T Köbe, U Grittner… - Cortex, 2018 - Elsevier
Introduction Nutritional intervention with the natural polyamine spermidine, an autophagy-
enhancing agent, can prevent memory loss in aging model organisms. This is the first …

[PDF][PDF] Memory takes time

NV Kukushkin, TJ Carew - Neuron, 2017 - cell.com
Memory is an adaptation to particular temporal properties of past events, such as the
frequency of occurrence of a stimulus or the coincidence of multiple stimuli. In neurons, this …

Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway

N Nitzan, S McKenzie, P Beed, DF English… - Nature …, 2020 - nature.com
Bouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate
communication between the hippocampus and neocortex. However, the paths and …