Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Cancer represents one of the most pernicious public health problems with a high mortality
rate among patients worldwide. Chemotherapy is one of the major therapeutic approaches …

Simple Summary Next-generation sequencing of head and neck squamous cell carcinoma
has revealed multiple new gene mutations, while simultaneously confirming the role of …

Purpose A significant portion of patients with locally advanced head and neck squamous
cell carcinoma (HNSCC) relapse despite multimodality treatment denoting the need for …

Salivary gland hypofunction is an adverse side effect associated with radiotherapy for head
and neck cancer patients. This study delineated metabolic changes at acute, intermediate …

Background Patients with cancer often endure substantial symptoms and treatment toxicities
leading to high healthcare utilization, including hospitalizations and emergency department …

Cisplatin (DDP)-based concurrent chemo-radiotherapy is a standard approach to treat
locoregionally advanced nasopharyngeal carcinoma (NPC). However, many patients …

Older patients with cancer, particularly those over 75 years of age, often experience poorer
clinical outcomes compared to younger patients. This can be attributed to age-related …

Simple Summary Many head-and-neck cancer patients assigned to chemoradiation cannot
receive concurrent cisplatin due to impaired renal function. Carboplatin may be an …

Cisplatin is broad-spectrum chemotherapeutic agent that has been widely used for the
treatment of a variety of malignant tumors including breast cancer. However, the cisplatin …