The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

As a member of the TRIM (tripartite motif) protein family, TRIM56 can function as an E3
ubiquitin ligase. In addition, TRIM56 has been shown to possess deubiquitinase activity and …

Ubiquitination is a post-translational modification that has pivotal roles in protein
degradation and diversified cellular processes, and for more than two decades it has been a …

Abstract Tripartite motif 8 (TRIM8) is an E3 ligase that plays dual roles in various tumor
types. The biological effects and underlying mechanism of TRIM8 in hepatocellular …

Simple Summary This study targeted the identification of rare variants in Middle Eastern
papillary thyroid carcinoma (PTC) through an exome-wide association study. It was found …

Simple Summary The TP53 tumor suppressor gene, the guardian of the genome, is mutated
or has an inactive pathway in most chemo-resistant tumors. Most studies focus on the role of …

Background With the advancement of early detection and treatment, the incidence of colon
cancer (CC) has declined steadily worldwide; however, the mortality remains unacceptably …

Simple Summary The tripartite motif (TRIM) gene family is a large group of E3 ubiquitin
ligase proteins that can also have proteasome-independent functions. This review …

Background The tripartite motif (TRIM) proteins have been reported to play crucial roles in
various malignancies. However, the clinical significance of TRIM proteins in colorectal …

The intake of selenium (Se) in the human body is negatively correlated with the risk of
colorectal cancer (CRC), but its mechanism in the occurrence and development of CRC is …