Lipoprotein (a): resurrected by genetics

F Kronenberg, G Utermann - Journal of internal medicine, 2013 - Wiley Online Library
Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …

Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology

BG Nordestgaard, A Langsted - Journal of lipid research, 2016 - ASBMB
Human epidemiologic and genetic evidence using the Mendelian randomization approach
in large-scale studies now strongly supports that elevated lipoprotein (a)[Lp (a)] is a causal …

Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.

E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …

The mysteries of lipoprotein (a)

G Utermann - Science, 1989 - science.org
Lipoprotein (a)[Lp (a)] is a macromolecular complex found in human plasma that combines
structural elements from the lipoprotein and blood clotting systems and that is associated …

Circulating lipoprotein (a) and all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis

M Amiri, H Raeisi-Dehkordi, AJCF Verkaar… - European journal of …, 2023 - Springer
Aims To investigate the association between circulating lipoprotein (a)(Lp (a)) and risk of all-
cause and cause-specific mortality in the general population and in patients with chronic …

Lipoprotein physiology

HN Ginsberg - Endocrinology and Metabolism Clinics, 1998 - endo.theclinics.com
The major neutral lipids transported through the blood stream, triglycerides and cholesteryl
esters, are insoluble in aqueous solutions and therefore must be protected from plasma by a …

Effects of the apolipoprotein (a) size polymorphism on the lipoprotein (a) concentration in 7 ethnic groups

C Sandholzer, DM Hallman, N Saha, G Sigurdsson… - Human genetics, 1991 - Springer
Summary Apolipoprotein (a)[apo (a)] exhibits a genetic size polymorphism explaining about
40% of the variability in lipoprotein (a)[Lp (a)] concentration in Tyroleans. Lp (a) …

[PDF][PDF] Lipoprotein (a). Heterogeneity and biological relevance.

AM Scanu, GM Fless - The Journal of clinical investigation, 1990 - Am Soc Clin Investig
Lipoprotein (a), or Lp (a),'discovered by KAre Berg (1) more than 25 years ago, remains
today a fascinating subject of research both because of its presumed association with athero …

Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis.

C Lackner, E Boerwinkle, CC Leffert… - The Journal of …, 1991 - Am Soc Clin Investig
Lipoprotein (a)[Lp (a)] is a cholesterol-rich lipoprotein that is distinguished by its content of a
glycoprotein called apolipoprotein (a)[apo (a)]. Apo (a) varies in size among individuals …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …