Abstract Sine Oculis Homeobox 1 (SIX1) is a member of homeobox transcription factor
family having pivotal roles in organismal development and differentiation. This protein …

Cellular senescence, a form of stable cell cycle arrest induced by cellular stress, constitutes
a major factor leading to the promotion of pathologies and physiological decays that take …

Background Mounting evidences indicate that circular RNAs (circRNAs) play vital roles in
the development and progression of various cancers. However, the detail functions and …

SIX homeoproteins were first described in Drosophila, where they participate in the Pax-Six-
Eya-Dach (PSED) network with eyeless, eyes absent and dachsund to drive synergistically …

Abstract The PAX-SIX-EYA-DACH network (PSEDN) is a central developmental
transcriptional regulatory network from Drosophila to humans. The PSEDN is comprised of …

Developmental senescence is a form of programmed senescence that contributes to
morphogenesis during embryonic development. We showed recently that the SIX1 …

Cell senescence is a state of limited cell proliferation during a stress response or as part of a
programmed process. When a senescent cell stops dividing, maintaining metabolic activity …

Cellular senescence is an antiproliferative response with a critical role in the control of
cellular balance in diverse physiological and pathological settings. Here, we set to study the …

Background and purpose MAPKs are among the most relevant signalling pathways involved
in coordinating cell responses to different stimuli. This group includes p38MAPKs …

Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors.
Recent results show that SIX1 also acts as a repressor of cell senescence, an …