Importance Septic shock currently refers to a state of acute circulatory failure associated with
infection. Emerging biological insights and reported variation in epidemiology challenge the …

Sepsis is a common and lethal syndrome: although outcomes have improved, mortality
remains high. No specific anti-sepsis treatments exist; as such, management of patients …

Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function …

Rationale: Reducing the global burden of sepsis, a recognized global health challenge,
requires comprehensive data on the incidence and mortality on a global scale. Objectives …

Background Sepsis is a leading cause of preventable death around the world. Population-
based estimation of sepsis incidence is lacking in China. In this study, we aimed to estimate …

Objective Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and
a high mortality rate. The aim of this consensus is to provide support to the bedside clinician …

Objective Sepsis is a complex and hard-to-define condition with many different interactions
with other disorders. Presently, there are no estimates of the burden of sepsis and …

Objective Shock is a severe syndrome resulting in multiple organ dysfunction and a high
mortality rate. The goal of this consensus statement is to provide recommendations …

Objective: To describe the outcome of patients with sepsis according to location on a ward or
in an intensive care unit. Design: Prospective multicentered observational study. Setting …

Introduction To evaluate the impact of recent evidence-based treatments for severe sepsis in
routine clinical care requires an understanding of the underlying epidemiology, particularly …