▪ Abstract Apoptosis, a physiological process for killing cells, is critical for the normal
development and function of multicellular organisms. Abnormalities in cell death control can …

Reactive oxygen species (ROS) are known mediators of intracellular signal cascades.
Excessive production of ROS may lead to oxidative stress, loss of cell function, and cell …

INTRODUCTION Despite the father transmitting half of the heritable information to the
embryo, the focus of preconception health has been the mother. Paternal effects have been …

The molecular control of self-renewal and differentiation of stem cells has remained
enigmatic. Transgenic loss-of-function and overexpression models now show that the …

Cellular apoptosis appears to be a constant feature in the adult testis and during early
development. This is essential because mammalian spermatogenesis is a complex process …

The incorporation of mitochondria in the eukaryotic cell is one of the most enigmatic events
in the course of evolution. This important organelle was thought to be only the powerhouse …

The molecular basis of many forms of male infertility is poorly defined. One area of research
that has been studied intensely is the integrity of the DNA in the nucleus of mature …

Humans are exposed occupationally and environmentally to metal aerosols including lead
(Pb2+) and cadmium (Cd2+). These toxicants accumulate in male reproductive organs …

Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal
cells show a highly abnormal adult spermatogenesis accompanied by sterility. This appears …

BACKGROUND: The relationship between early embryo post-implantation development in
couples undergoing assisted reproductive techniques (ARTs) and sperm chromatin …