This is the first systematic review of the safety of ketamine in the treatment of depression
after single and repeated doses. We searched MEDLINE, PubMed, PsycINFO, and …

Background Over the past 2 decades, the use of intravenous ketamine infusions as a
treatment for chronic pain has increased dramatically, with wide variation in patient …

Importance Several studies now provide evidence of ketamine hydrochloride's ability to
produce rapid and robust antidepressant effects in patients with mood and anxiety disorders …

Human studies examining the effects of the dissociative anesthetic ketamine as a model for
psychosis and as a rapidly acting antidepressant have spurred great interest in …

Over a third of patients with major depressive disorder (MDD) do not have an adequate
response to first-line antidepressant treatments, ie, they have treatment-resistant depression …

Abstract (R, S)-ketamine (ketamine) and its enantiomer (S)-ketamine (esketamine) can
produce rapid and substantial antidepressant effects. However, individual response to …

Ketamine produces a rapid antidepressant response in over 50% of adults with treatment-
resistant depression. A long infusion of ketamine may provide durable remission of …

Background: Ketamine has proven to have rapid, robust antidepressant effects on treatment-
resistant depression. However, whether repeated ketamine infusions would cause short-and …

Introduction Ketamine treatment is capable of significant and rapid symptom improvement in
adults with treatment-resistant depression (TRD). A limitation of ketamine treatment in TRD …

Background The increasing use of ketamine as a potential rapid-onset antidepressant
necessitates a better understanding of its effects on blood pressure and heart rate, well …