Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver, or
brain. Genomic, proteomic, and metabolomic approaches highlight common injury …

Kidney transplantation is the treatment of choice in patients with end stage renal disease.
During kidney transplantation ischemia reperfusion injury (IRI) occurs, which is a risk factor …

Abstract Background Mesenchymal stromal cells (MSCs) and renal stem/progenitors
improve the recovery of acute kidney injury (AKI) mainly through the release of paracrine …

Background Cell-based regenerative medicine therapies are now frequently tested in
clinical trials. In many conditions, cell therapies are administered systemically, but there is …

Distal lung diseases, such as pulmonary fibrosis or acute lung injury, are commonly
associated with local alveolar hypoxia that may be deleterious through the stimulation of …

Chronic kidney disease (CKD) is the irreversible loss of nephron function, leading to a build-
up of toxins, prolonged inflammation, and ultimately fibrosis. Currently, no effective therapies …

Voiding dysfunction encompasses a wide range of urologic disorders including stress
urinary incontinence and overactive bladder that have a detrimental impact on the quality of …

Ischemic kidney diseases are common clinical entities that bear high mortality and morbidity
and may lead to irreversible loss of kidney function. Their pathophysiology is multifaceted …

The ability of the human kidney to repair itself is limited. Consequently, repeated injury can
trigger a maladaptive response that is characterized by fibrosis and loss of renal function …

Animal studies have shown that mesenchymal stromal cell (MSC) infusions improve acute
kidney injury (AKI) outcomes when administered early after ischemic/reperfusion injury or …