Dosing limitation for intra-renal arterial infusion of mesenchymal stromal cells

A Munk, CS Duvald, M Pedersen, S Lohmann… - International Journal of …, 2022 - mdpi.com
The immunomodulatory and regenerative properties of mesenchymal stromal cells (MSCs)
make MSC therapy a promising therapeutic strategy in kidney disease. A targeted MSC …

In vivo survival of mesenchymal stromal cell–enhanced decellularized nerve grafts for segmental peripheral nerve reconstruction

N Rbia, LF Bulstra, R Thaler, SER Hovius… - The Journal of hand …, 2019 - Elsevier
Purpose Adipose-derived mesenchymal stromal cells (MSCs) have emerged as promising
tools for peripheral nerve reconstruction. There is a paucity of information regarding the …

Mesenchymal stem cells therapy for acute kidney injury: a systematic review with meta-analysis based on rat model

P Wanyan, X Wang, N Li, Y Huang, Y She… - Frontiers in …, 2023 - frontiersin.org
Objective: To systematically evaluate the efficacy of mesenchymal stem cells (MSCs) for
acute kidney injury (AKI) in preclinical studies and to explore the optimal transplantation …

Protective effect and localization by optical imaging of human renal CD133+ progenitor cells in an acute kidney injury model

C Grange, A Moggio, M Tapparo, S Porta… - Physiological …, 2014 - Wiley Online Library
Recent approaches of regenerative medicine can offer a therapeutic option for patients
undergoing acute kidney injury. In particular, mesenchymal stem cells were shown to …

Maximum efficacy of mesenchymal stem cells in rat model of renal ischemia-reperfusion injury: renal artery administration with optimal numbers

J Cai, X Yu, R Xu, Y Fang, X Qian, S Liu, J Teng… - PloS one, 2014 - journals.plos.org
Backgrounds Despite the potential therapeutic benefits, cell therapy in renal ischemia-
reperfusion (I/R) injury is currently limited by low rates of cell engraftment after systemic …

[PDF][PDF] Molecular mechanisms of migration and homing of intravenously transplanted mesenchymal stem cells

IV Kholodenko, AA Konieva, RV Kholodenko… - J Regen Med Tissue …, 2013 - academia.edu
Mesenchymal stem cells (MSCs) isolated from various tissues are currently regarded as one
of the most convenient starting materials for preparation of cell therapy and tissue …

Concise review: stem/progenitor cells for renal tissue repair: current knowledge and perspectives

S Aggarwal, A Moggio… - Stem Cells Translational …, 2013 - academic.oup.com
The kidney is a specialized low-regenerative organ with several different types of cellular
lineages; however, the identity of renal stem/progenitor cells with nephrogenic potential and …

Locoregional delivery of stem cell–based therapies

NN Ng, AS Thakor - Science translational medicine, 2020 - science.org
Interventional regenerative medicine (IRM) uses image-guided, minimally invasive
procedures for the targeted delivery of stem cell–based therapies to regenerate, replace, or …

In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging

J Cao, S Hou, H Ding, Z Liu, M Song, X Qin… - Stem cells …, 2016 - Wiley Online Library
Recently, mesenchymal stem cells (MSCs) are increasingly used as a panacea for multiple
types of disease short of effective treatment. Dozens of clinical trials published demonstrated …

Does the route matter? A preclinical review of mesenchymal stromal cell delivery to the kidney

JC Kresse, E Gregersen, JCL Atay, M Eijken… - Apmis, 2023 - Wiley Online Library
Mesenchymal stromal/stem cell (MSC) therapy has been thoroughly tested in preclinical
animal models and holds great promise for the treatment of kidney diseases. It is becoming …