[HTML][HTML] Targeting FLT3 mutations in AML: review of current knowledge and evidence
Genomic investigations of acute myeloid leukemia (AML) have demonstrated that several
genes are recurrently mutated, leading to new genomic classifications, predictive …
genes are recurrently mutated, leading to new genomic classifications, predictive …
DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin
J Du, T Wang, Y Li, Y Zhou, X Wang, X Yu… - Free Radical Biology …, 2019 - Elsevier
Dihydroartemisinin (DHA) has been shown to be capable of inhibiting cancer growth,
whereas it remains largely elusive that the underlying molecular mechanism of DHA …
whereas it remains largely elusive that the underlying molecular mechanism of DHA …
[HTML][HTML] Time to repeal and replace response criteria for acute myeloid leukemia?
CD Bloomfield, E Estey, L Pleyer, AC Schuh, EM Stein… - Blood reviews, 2018 - Elsevier
Abstract The International Working Group (IWG) response criteria for acute myeloid
leukemia, published in 2003, have remained the standard by which the efficacy of new …
leukemia, published in 2003, have remained the standard by which the efficacy of new …
[HTML][HTML] Targeting miR-126 in inv (16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance
L Zhang, LXT Nguyen, YC Chen, D Wu… - Nature …, 2021 - nature.com
Acute myeloid leukemia (AML) harboring inv (16)(p13q22) expresses high levels of miR-
126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 …
126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 …
DeSUMOylation of chromatin-bound proteins limits the rapid transcriptional reprogramming induced by daunorubicin in acute myeloid leukemias
M Boulanger, M Aqrouq, D Tempé, C Kifagi… - Nucleic Acids …, 2023 - academic.oup.com
Genotoxicants have been used for decades as front-line therapies against cancer on the
basis of their DNA-damaging actions. However, some of their non-DNA-damaging effects …
basis of their DNA-damaging actions. However, some of their non-DNA-damaging effects …
[HTML][HTML] Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia
Background Current conventional chemotherapy for acute myeloid leukemia (AML) can
achieve remission in over 70% of patients, but a majority of them will relapse within 5 years …
achieve remission in over 70% of patients, but a majority of them will relapse within 5 years …
[HTML][HTML] The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity …
I Spinello, E Saulle, MT Quaranta, L Pasquini… - …, 2019 - ncbi.nlm.nih.gov
CD147 is a transmembrane glycoprotein with multiple functions in human healthy tissues
and diseases, in particular in cancer. Overexpression of CD147 correlates with biological …
and diseases, in particular in cancer. Overexpression of CD147 correlates with biological …
[HTML][HTML] Selective expression of Flt3 within the mouse hematopoietic stem cell compartment
CJ Mooney, A Cunningham, P Tsapogas… - International journal of …, 2017 - mdpi.com
The fms-like tyrosine kinase 3 (Flt3) is a cell surface receptor that is expressed by various
hematopoietic progenitor cells (HPC) and Flt3-activating mutations are commonly present in …
hematopoietic progenitor cells (HPC) and Flt3-activating mutations are commonly present in …
[HTML][HTML] The PI3K/mTOR dual inhibitor BEZ235 suppresses proliferation and migration and reverses multidrug resistance in acute myeloid leukemia
L Deng, L Jiang, X Lin, KF Tseng, Y Liu… - Acta Pharmacologica …, 2017 - nature.com
Aberrant activation of the PI3K/Akt/mTOR pathway contributes to the proliferation of
malignant cells, and may confer resistance to chemotherapy in various malignancies …
malignant cells, and may confer resistance to chemotherapy in various malignancies …
High serum extracellular vesicle miR-10b expression predicts poor prognosis in patients with acute myeloid leukemia
Z Fang, X Wang, J Wu, R Xiao, J Liu - Cancer Biomarkers, 2020 - content.iospress.com
BACKGROUND: Increasing evidence have demonstrated that serum extracellular vesicle
microRNAs (EV-miRNAs) are promising noninvasive biomarkers for various cancer types …
microRNAs (EV-miRNAs) are promising noninvasive biomarkers for various cancer types …