[HTML][HTML] Immunoendocrine dysregulation during gestational diabetes mellitus: The central role of the placenta

A Olmos-Ortiz, P Flores-Espinosa, L Díaz… - International Journal of …, 2021 - mdpi.com
Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …

The role of endoglin and its soluble form in pathogenesis of preeclampsia

G Margioula-Siarkou, C Margioula-Siarkou… - Molecular and Cellular …, 2022 - Springer
Preeclampsia remains till today a leading cause of maternal and fetal morbidity and
mortality. Pathophysiology of the disease is not yet fully elucidated, though it is evident that it …

Inhibition of ALKBH5‐mediated m6A modification of PPARG mRNA alleviates H/R‐induced oxidative stress and apoptosis in placenta trophoblast

Y Guo, W Song, Y Yang - Environmental Toxicology, 2022 - Wiley Online Library
The alpha‐ketoglutarate‐dependent (ALKB) homolog 5 (ALKBH5), an m6A demethylase,
has been reported to be involved in the pathogenesis of preeclampsia (PE), but the exact …

[HTML][HTML] Insight into the key points of preeclampsia pathophysiology: uterine artery remodeling and the role of MicroRNAs

K Pankiewicz, A Fijałkowska, T Issat… - International journal of …, 2021 - mdpi.com
Preeclampsia affects about 3–8% of all pregnancies. It represents a complex and
multifaceted syndrome with at least several potential pathways leading to the development …

[HTML][HTML] Role of microRNAs in trophoblast invasion and spiral artery remodeling: implications for preeclampsia

H Hayder, Y Shan, Y Chen, JA O'Brien… - Frontiers in Cell and …, 2022 - frontiersin.org
It is now well-established that microRNAs (miRNAs) are important regulators of gene
expression. The role of miRNAs in placental development and trophoblast function is …

[HTML][HTML] Soluble endoglin reduces thrombus formation and platelet aggregation via interaction with αIIbβ3 integrin

E Rossi, M Pericacho, A Kauskot… - Journal of Thrombosis …, 2023 - Elsevier
Background The circulating form of human endoglin (sEng) is a cleavage product of
membrane-bound endoglin present on endothelial cells. Because sEng encompasses an …

Animal models of cardiovascular complications of pregnancy

Z Arany, D Hilfiker-Kleiner, SA Karumanchi - Circulation research, 2022 - Am Heart Assoc
Cardiovascular complications of pregnancy have risen substantially over the past decades,
and now account for the majority of pregnancy-induced maternal deaths, as well as having …

Novel vascular roles of human endoglin in pathophysiology

E Rossi, C Bernabeu - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
Endoglin, alias CD105, is a human membrane glycoprotein highly expressed in vascular
endothelial cells. It is involved in angiogenesis and in angiogenesis-related diseases …

[HTML][HTML] Hot and cold tumors: is endoglin (CD105) a potential target for vessel normalization?

C Ollauri-Ibáñez, B Ayuso-Íñigo, M Pericacho - Cancers, 2021 - mdpi.com
Tumors are complex masses formed by malignant but also by normal cells. The interaction
between these cells via cytokines, chemokines, growth factors, and enzymes that remodel …

[HTML][HTML] Effect of somatic antigens of Dirofilaria repens adult worms on angiogenesis, cell proliferation and migration and pseudo-capillary formation in human …

MP Pérez Rodríguez, C Alarcón-Torrecillas… - Parasites & …, 2023 - Springer
Background Angiogenesis is defined as the formation of new vessels by sprouting of
endothelial cells from pre-existing vessels in response to stimuli, such as hypoxia or …