Characterization of isomeric glycan structures by LC‐MS/MS

L Veillon, Y Huang, W Peng, X Dong, BG Cho… - …, 2017 - Wiley Online Library
The characterization of glycosylation is critical for obtaining a comprehensive view of the
regulation and functions of glycoproteins of interest. Due to the complex nature of …

MS‐based glycomics and glycoproteomics methods enabling isomeric characterization

W Peng, CD Gutierrez Reyes, S Gautam… - Mass Spectrometry …, 2023 - Wiley Online Library
Glycosylation is one of the most significant and abundant posttranslational modifications in
mammalian cells. It mediates a wide range of biofunctions, including cell adhesion, cell …

Advances in mass spectrometry‐based glycoproteomics

A Yu, J Zhao, W Peng, A Banazadeh… - …, 2018 - Wiley Online Library
Protein glycosylation, an important PTM, plays an essential role in a wide range of biological
processes such as immune response, intercellular signaling, inflammation, and host …

Advances in mass spectrometry‐based glycomics

X Dong, Y Huang, BG Cho, J Zhong, S Gautam… - …, 2018 - Wiley Online Library
The diversification of the chemical properties and biological functions of proteins is attained
through posttranslational modifications, such as glycosylation. Glycans, which are covalently …

Advances in mass spectrometry‐based glycomics—An update covering the period 2017–2021

KB Donohoo, J Wang, M Goli, A Yu, W Peng… - …, 2022 - Wiley Online Library
The wide variety of chemical properties and biological functions found in proteins is attained
via post‐translational modifications like glycosylation. Covalently bonded to proteins …

Advances in mass spectrometry‐based glycoproteomics: an update covering the period 2017–2021

CD Gutierrez‐Reyes, P Jiang, M Atashi… - …, 2022 - Wiley Online Library
Protein glycosylation is one of the most common posttranslational modifications, and plays
an essential role in a wide range of biological processes such as immune response …

Revealing the biological attributes of N-glycan isomers in breast cancer brain metastasis using porous graphitic carbon (PGC) liquid chromatography-tandem mass …

W Peng, M Goli, P Mirzaei… - Journal of proteome …, 2019 - ACS Publications
Breast cancer is a leading cancer in women and is considered to be the second-most
common metastatic cancer following lung cancer. An estimated 10–16% of breast cancer …

Clinical application of quantitative glycomics

W Peng, J Zhao, X Dong, A Banazadeh… - Expert review of …, 2018 - Taylor & Francis
Introduction: Aberrant glycosylation has been associated with many diseases. Decades of
research activities have reported many reliable glycan biomarkers of different diseases …

Challenges for biosimilars: focus on rheumatoid arthritis

MS Akram, N Pery, L Butler, MI Shafiq… - Critical reviews in …, 2021 - Taylor & Francis
Healthcare systems worldwide are struggling to find ways to fund the cost of innovative
treatments such as gene therapies, regenerative medicine, and monoclonal antibodies …

Integrated transcriptomics, proteomics, and glycomics reveals the association between up-regulation of sialylated N-glycans/integrin and breast cancer brain …

W Peng, R Zhu, S Zhou, P Mirzaei, Y Mechref - Scientific reports, 2019 - nature.com
Breast cancer brain metastasis has been recognized as one of the central issues in breast
cancer research. The elucidation of the processes and pathways that mediate this step will …