Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …

Discovered just over 20 years ago, dopamine neurons have the ability to cotransmit both
dopamine and glutamate. Yet, the functional roles of dopamine neuron glutamate …

Dopamine neurons project to the striatum to control movement, cognition, and motivation via
slower volume transmission as well as faster dopamine, glutamate, and GABA synaptic …

The pervasiveness and mortality associated with methamphetamine abuse has doubled
during the past decade suggesting a possible worldwide substance use crisis. Epitomizing …

GLT-1, the major glutamate transporter in the mammalian central nervous system, is
expressed in presynaptic terminals that use glutamate as a neurotransmitter, in addition to …

Introduction: Methamphetamine (METH) is an addictive psychostimulant that facilitates
dopamine transmission to the nucleus accumbens (NAc), resulting in alterations in the …

Receiving a neurodegenerative disease (NDD) diagnosis, such as Alzheimer's disease,
Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis, is devastating …

Abstract Purpose of Review Disruptions in glutamate hemostasis have been implicated in
cocaine use disorder (CUD). This manuscript reviews novel agents that influence glutamate …

Histidine metabolism is a key pathway physiologically involved in satiety, recognition
memory, skin, and neural protection and allergic diseases. Microbiologically‐produced …

Drug addiction is one of the major worldwide health problems, which will have serious
adverse consequences on human health and significantly burden the social economy and …