Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Neurotransmitters serve as chemical messengers playing a crucial role in information
processing throughout the nervous system, and are essential for healthy physiological and …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Aberrant localization of proteins to mitochondria disturbs mitochondrial function and
contributes to the pathogenesis of Huntington's disease (HD). However, the crucial factors …

The purpose of our study is to determine the protective effects of mitophagy enhancers
against phosphorylated tau (P-tau)-induced mitochondrial and synaptic toxicities in …

One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …

Huntington's disease is a genetic disease caused by expanded CAG repeats on exon 1 of
the huntingtin gene located on chromosome 4. Compelling evidence implicates impaired …

Mitochondria are the primary cellular energy generators, supplying the majority of
adenosine triphosphate through oxidative phosphorylation, which is necessary for neuron …

Huntington's disease (HD) is a progressive dominantly inherited neurodegenerative disease
caused by the expansion of a cytosine-adenine-guanine (CAG) trinucleotide repeat in the …

Through their role in energy generation and regulation of several vital pathways, including
apoptosis and inflammation, mitochondria are critical for the life of eukaryotic organisms …