Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …

Mobile DNAs, also known as transposons or 'jumping genes', are widespread in nature and
comprise an estimated 45% of the human genome. Transposons are divided into two …

DNA methylation is the most widely studied epigenetic mark and is known to be essential to
normal development and frequently disrupted in disease. The Illumina …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of
human cancer genetics. But this area has become increasingly visible with a growing …

Chemical modifications to DNA and histone proteins form a complex regulatory network that
modulates chromatin structure and genome function. The epigenome refers to the complete …

We describe a large-scale random approach termed reduced representation bisulfite
sequencing (RRBS) for analyzing and comparing genomic methylation patterns. BglII …

The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …

Changes in human DNA methylation patterns are an important feature of cancer
development and progression and a potential role in other conditions such as …