Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …

Over the past decade, the study of metabolic abnormalities in cancer cells has risen
dramatically. Cancer cells can thrive in challenging environments, be it the hypoxic and …

Microbes and their byproducts have been reported to regulate host health and immune
functions. Here we demonstrated that microbial exopolysaccharide produced by …

Non–small cell lung cancers that harbor concurrent KRAS and TP53 (KP) mutations are
immunologically warm tumors with partial responsiveness to anti–PD-(L) 1 blockade; …

Lysophospholipids (LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate
(S1P), lysophosphatidylinositol (LPI), and lysophosphatidylserine (LysoPS), are bioactive …

In recent decades, great advances have been made in the field of tumor treatment.
Especially, cell-based therapy targeting tumor associated antigen (TAA) has developed …

Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and
systemically across different cancer types. Yet, the exact mechanism (s) of how LPA affects …

Autotaxin (ATX), or ecto-nucleotide pyrophosphatase/phosphodiesterase-2, is a secreted
lysophospholipase D (lysoPLD) that hydrolyzes extracellular lysophospholipids into the lipid …

Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main
membrane‐derived lipid signaling molecules. LPA acts as an autocrine/paracrine …

Ovarian cancer ascites is a native medium for cancer cells that allows investigation of their
secretome in a natural environment. This medium is of interest as a promising source of …