Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

Septins are conserved guanine nucleotide-binding proteins that polymerize into filaments at
the cell cortex or in association with other cytoskeletal proteins, such as actin or …

Most human cells require anchorage for survival. Cell–substrate adhesion activates diverse
signalling pathways, without which cells undergo anoikis—a form of programmed cell death …

Cells change shape in response to diverse environmental and developmental conditions,
creating topologies with micron-scale features. Although individual proteins can sense …

Septins are GTP-binding proteins that form filaments and higher-order structures on the cell
cortex of eukaryotic cells and associate with actin and microtubule cytoskeletal networks …

The actin and microtubule cytoskeletons comprise a variety of networks with distinct
architectures, dynamics and protein composition. A fundamental question in eukaryotic cell …

Organogenesis and tumor metastasis involve the transformation of epithelia to highly motile
mesenchymal-like cells. Septins are filamentous G proteins, which are overexpressed in …

Septins perform diverse functions through the formation of filaments and higher-order
structures. However, the exact architecture of septin structures remains unclear. In the …

In order to form functional filaments, human septins must assemble into hetero-oligomeric
rod-like particles which polymerize end-to-end. The rules governing the assembly of these …

Abscission is the terminal step of mitosis that physically separates two daughter cells [1, 2].
Abscission requires the endocytic sorting complex required for transport (ESCRT), a …