Artificial intelligence-enabled quantitative phase imaging methods for life sciences

J Park, B Bai, DH Ryu, T Liu, C Lee, Y Luo, MJ Lee… - Nature …, 2023 - nature.com
Quantitative phase imaging, integrated with artificial intelligence, allows for the rapid and
label-free investigation of the physiology and pathology of biological systems. This review …

[HTML][HTML] On the use of deep learning for phase recovery

K Wang, L Song, C Wang, Z Ren, G Zhao… - Light: Science & …, 2024 - nature.com
Phase recovery (PR) refers to calculating the phase of the light field from its intensity
measurements. As exemplified from quantitative phase imaging and coherent diffraction …

Perspectives on liquid biopsy for label‐free detection of “circulating tumor cells” through intelligent lab‐on‐chips

L Miccio, F Cimmino, I Kurelac, MM Villone, V Bianco… - View, 2020 - Wiley Online Library
Circulating tumor cells (CTCs) are rare tumor cells released from primary, metastatic, or
recurrent tumors in the peripheral blood of cancer patients. CTCs isolation from peripheral …

Identification of microplastics based on the fractal properties of their holographic fingerprint

V Bianco, D Pirone, P Memmolo, F Merola… - ACS …, 2021 - ACS Publications
Water plastic pollution is a serious problem affecting sealife, marine habitats, and the food
chain. Artificial intelligence-enabled coherent imaging has recently shown exciting …

[HTML][HTML] Machine learning assisted classification of cell lines and cell states on quantitative phase images

AV Belashov, AA Zhikhoreva, TN Belyaeva, AV Salova… - Cells, 2021 - mdpi.com
In this report, we present implementation and validation of machine-learning classifiers for
distinguishing between cell types (HeLa, A549, 3T3 cell lines) and states (live, necrosis …

Neuroblastoma cells classification through learning approaches by direct analysis of digital holograms

MD Priscoli, P Memmolo, G Ciaparrone… - IEEE Journal of …, 2021 - ieeexplore.ieee.org
The label-free single cell analysis by machine and Deep Learning, in combination with
digital holography in transmission microscope configuration, is becoming a powerful …

Comparative analysis of Radachlorin accumulation, localization, and photobleaching in three cell lines by means of holographic and fluorescence microscopy

AA Zhikhoreva, AV Belashov, TN Belyaeva… - Photodiagnosis and …, 2022 - Elsevier
In this paper we compare the response of cells of established lines of different origin: HeLa,
A549 and 3T3 to photodynamic treatment with Radachlorin photosensitizer. The analysis …

[HTML][HTML] Holographic flow scanning cytometry overcomes depth of focus limits and smartly adapts to microfluidic speed

Z Wang, V Bianco, PL Maffettone, P Ferraro - Lab on a Chip, 2023 - pubs.rsc.org
Space-time digital holography (STDH) maps holograms in a hybrid space-time domain to
achieve extended field of view, resolution enhanced, quantitative phase-contrast microscopy …

[HTML][HTML] Significant difference in response of malignant tumor cells of individual patients to photodynamic treatment as revealed by digital holographic microscopy

AA Zhikhoreva, AV Belashov, AB Danilova… - … of Photochemistry and …, 2021 - Elsevier
The investigation of in-vitro response of cell cultures derived from tumor material of
individual patients with similar tumor localizations to photodynamic treatment is presented …

Classification of cell morphology with quantitative phase microscopy and machine learning

Y Li, J Di, K Wang, S Wang, J Zhao - Optics Express, 2020 - opg.optica.org
We describe and compare two machine learning approaches for cell classification based on
label-free quantitative phase imaging with transport of intensity equation methods. In one …