Background Hypersensitivity reactions (HSR) to the administration of infliximab (IFX) in
Inflammatory Bowel Diseases (IBD) patients are not rare and usually lead to drug …

Introduction This study aimed to retrospectively examine the drug survival of tumor necrosis
factor (TNF)-alpha inhibitors and switched subsequent biologic agents after discontinuation …

Monoclonal antibodies against tumor necrosis factor-alpha (TNFα) are widely used for
treatment of inflammatory diseases. However, despite the inhibitory effect this class of drugs …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint
inflammation. In recent decades, biological agents such as anti-tumor necrosis factor-α (TNF …

Introduction Adalimumab (ADA) and etanercept (ETN) are the most commonly applied
biologics for rheumatoid arthritis (RA) management in China; however, the evidence …

Monitoring anti-drug antibodies (ADAs) to infliximab and adalimumab is critical to treatment
management in various autoimmune disorders. The growing need for proactive therapeutic …

Deficiency of adenosine deaminase 2 (DADA2), first reported in 2014, is a disease with
great phenotypic variability, which has been increasingly reported. Therapeutic response …

Objectives To compare the drug survival of etanercept to monoclonal tumour necrosis factor-
α inhibitors in rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Methods …

结直肠癌是消化道常见恶性肿瘤, 炎症性肠病发展为结直肠癌的风险显著增加. 免疫信号通路NF-
κB, IL-6/STAT3, COX-2/PGE2, IL-23/Th17, TLRs 等已被证实能够促进结肠炎向结直肠癌转化 …

Background Systemic treatment patterns and related mental health disorders and economic
burden among patients with psoriasis are largely unknown. Objective To assess systemic …