Angiogenesis is the process through which novel blood vessels are formed from pre-existing
ones and it is involved in both physiological and pathological processes of the body …

Distinct from classical tumor angiogenesis, vasculogenic mimicry (VM) provides a blood
supply for tumor cells independent of endothelial cells. VM has two distinct types, namely …

Angiogenesis is involved in physiological and pathological processes in the body. Tumor
angiogenesis is a key factor associated with tumor growth, progression, and metastasis …

Cancer patients have a shorter life expectancy because of metastasis, which is the dynamic
chain of events that leads to the spread of tumour cells to distant places inside the body …

Background B-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which
possess four conserved Bcl-2 homologies (BH) domains. Among the BH domains, the BH3 …

Background: Vascular permeability (VP) is a fundamental aspect of vascular biology. A
growing number of studies have revealed that many signalling pathways govern VP in both …

The structure and function of the cardiovascular system are modulated across the day by
circadian rhythms, making this system susceptible to circadian rhythm disruption. Recent …

The heterogeneity of cancer cells, in part maintained via the expression of multiple isoforms,
introduces significant challenges in designing effective therapeutic approaches. In this …

The immune imbalance caused by excessive inflammatory reactions is the primary cause of
sepsis. Macrophages with M1 and M2 polarization states are important immune cells that …

Vascular endothelial growth factor (VEGF) not only serves as an autocrine survival factor for
tumor cells themselves, but also stimulates angiogenesis by paracrine pathway. Strategies …