基于网络药理学探究布地奈德治疗IgA 肾病的作用机制
张康， 赵婷婷， 张波， 高梦琦， 李昱熹， 王邵鹏， 赵文景 - 中国全科医学, 2023 - chinagp.net
背景IgA 肾病是我国及世界范围最常见的原发性肾小球肾炎, 25%~ 30% 的患者在确诊后20
年内会进展至终末期肾病. 目前尚无针对IgA 肾病有效且安全的治疗方案. 近年来针对IgA …
年内会进展至终末期肾病. 目前尚无针对IgA 肾病有效且安全的治疗方案. 近年来针对IgA …
Inhibitory effects of Eplerenone on angiogenesis via modulating SGK1/TGF-β pathway in contralateral kidney of CKD pregnancy rats
W Zhou, C Xu, J Niu, Y Xiong, Z He, H Xu, M Zhang… - Cellular …, 2024 - Elsevier
Background Eplerenone is a selective aldosterone receptor blocker that is effective in
preventing the progression of chroinic kidney disease (CKD). However, its mechanism and …
preventing the progression of chroinic kidney disease (CKD). However, its mechanism and …
Dysregulation of angiotensin converting enzyme 2 expression and function in comorbid disease conditions possibly contributes to coronavirus infectious disease 2019 …
ACE2 has emerged as a double agent in the COVID-19 ordeal, as it is both physiologically
protective and virally conducive. The identification of ACE2 in as many as 72 tissues …
protective and virally conducive. The identification of ACE2 in as many as 72 tissues …
Comprehensive analyses of the microRNA–messenger RNA–transcription factor regulatory network in mouse and human renal fibrosis
L Deng, G Xu, Q Huang - Frontiers in Genetics, 2022 - frontiersin.org
Objective: The aim of this study was to construct a microRNA (miRNA)–messenger RNA
(mRNA)–transcription factor (TF) regulatory network and explore underlying molecular …
(mRNA)–transcription factor (TF) regulatory network and explore underlying molecular …
Multiplex analysis of circulating maternal cardiovascular biomarkers comparing preeclampsia subtypes
Preeclampsia, a hypertensive pregnancy disorder, links to increased long-term maternal
cardiovascular disease (CVD). The risk is further increased with early-onset preeclampsia …
cardiovascular disease (CVD). The risk is further increased with early-onset preeclampsia …
Investigation of the pharmacological effect and mechanism of mountain-cultivated ginseng and garden ginseng in cardiovascular diseases based on network …
T Yu, YX Zhang, XJ Liu, DQ Chen, DD Wang… - Frontiers in …, 2022 - frontiersin.org
Ginseng (Panax ginseng CA Mey) is a kind of perennial herb of the Panax genus in the
Araliaceae family. The secondary metabolites of mountain-cultivated ginseng (MCG) and …
Araliaceae family. The secondary metabolites of mountain-cultivated ginseng (MCG) and …
Nuclear receptor 4A1 ameliorates renal fibrosis by inhibiting vascular endothelial growth factor A induced angiogenesis in UUO rats
H Wang, F Fang, M Zhang, C Xu, J Liu, L Gao… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Introduction Angiogenesis is closely related to renal fibrosis; however, its basic mechanism
remains unclear. In our study, we found that nuclear receptor 4A1 (NR4A1) inhibits vascular …
remains unclear. In our study, we found that nuclear receptor 4A1 (NR4A1) inhibits vascular …
Association between urinary VEGFA and renal pathology of IgA nephropathy patients
S Feng, N Huang, M Xue, P Zhang… - Journal of Clinical …, 2021 - Wiley Online Library
Background Renal biopsy remains the golden standard for diagnosing and monitoring IgA
nephropathy (IgAN). Vascular endothelial growth factor A (VEGFA) was crucial for the …
nephropathy (IgAN). Vascular endothelial growth factor A (VEGFA) was crucial for the …
Исследование эндотелиального фактора роста сосудов, маркеров воспаления и жесткости сосудов при хронической болезни почек
ИТ Муркамилов, КА Айтбаев, ВВ Фомин… - Клиническая …, 2020 - elibrary.ru
Цель исследования. Оценка уровней эндотелиального фактора роста сосудов (VEGF,
пг/мл), маркеров воспаления и их взаимосвязи с индексами жесткости сосудов при …
пг/мл), маркеров воспаления и их взаимосвязи с индексами жесткости сосудов при …
Platelet microvesicles promote the recovery of neurological function in mouse model of cerebral infarction by inducing angiogenesis
Q Wang, J Wei, Y Shi - Biochemical and biophysical research …, 2019 - Elsevier
The aim of this study is to investigate the effect of PMVs on mice with ischemic cerebral
infarction and its mechanism. Male C57BL/6 mice were selected, and the right focal cortical …
infarction and its mechanism. Male C57BL/6 mice were selected, and the right focal cortical …