Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation

S Madireddy, S Madireddy - Brain sciences, 2023 - mdpi.com
Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …

[HTML][HTML] Epilepsy: Mitochondrial connections to the 'Sacred'disease

WH Moos, DV Faller, IP Glavas, I Kanara, K Kodukula… - Mitochondrion, 2023 - Elsevier
Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated
biomarkers specific for myriad forms of epilepsy makes diagnosis challenging. Diagnosis …

The structural connectivity mapping of the intralaminar thalamic nuclei

VJ Kumar, K Scheffler, W Grodd - Scientific Reports, 2023 - nature.com
The intralaminar nuclei of the thalamus play a pivotal role in awareness, conscious
experience, arousal, sleep, vigilance, as well as in cognitive, sensory, and sexual …

Mapping hippocampal and thalamic atrophy in epilepsy: A 7‐T magnetic resonance imaging study

A Lucas, S Mouchtaris, A Tranquille, N Sinha… - …, 2024 - Wiley Online Library
Objective Epilepsy patients are often grouped together by clinical variables. Quantitative
neuroimaging metrics can provide a data‐driven alternative for grouping of patients. In this …

Low-frequency stimulation at the subiculum prevents extensive secondary epileptogenesis in temporal lobe epilepsy

Y Shen, Y Gong, X Da, S Gao, S Zhang, M Sun… - Neuroscience …, 2024 - Springer
Secondary epileptogenesis is characterized by increased epileptic susceptibility and a
tendency to generate epileptiform activities outside the primary focus. It is one of the major …

The Utility of Responsive Neurostimulation for the Treatment of Pediatric Drug-Resistant Epilepsy

MG Piazza, G Varga, W Welch, TJ Abel - Brain Sciences, 2023 - mdpi.com
Drug-resistant epilepsy (DRE) has a strongly negative impact on quality of life, as well as the
development of pediatric patients. Surgical treatments have evolved over time, including …

[HTML][HTML] Neuronal population representation of human emotional memory

D Fetterhoff, M Costa, R Hellerstedt, R Johannessen… - Cell Reports, 2024 - cell.com
Understanding how emotional processing modulates learning and memory is crucial for the
treatment of neuropsychiatric disorders characterized by emotional memory dysfunction. We …

Predictors of therapeutic response following thalamic neuromodulation for drug‐resistant pediatric epilepsy: A systematic review and individual patient data meta …

A Sharma, M Parfyonov, J Tiefenbach, O Hogue… - …, 2024 - Wiley Online Library
We sought to perform a systematic review and individual participant data meta‐analysis to
identify predictors of treatment response following thalamic neuromodulation in pediatric …

Ventral amygdalofugal pathway as an integrated surgically important network: microsurgical anatomy and segmentation based on fiber dissection

B Erkan, B Hergünsel, O Barut, T Saygı, B Kocak… - Journal of …, 2024 - thejns.org
OBJECTIVE The ventral amygdalofugal pathway (VAFP) provides afferent and efferent
connections to the amygdala and spans along some of the frequently traversed intra-axial …

Thalamic stereoelectroencephalography for neuromodulation target selection: Proof of concept and review of literature of pulvinar direct electrical stimulation

N Ikegaya, T Aung, A Mallela, JL Hect, A Damiani… - …, 2024 - Wiley Online Library
In patients with drug‐resistant epilepsy (DRE) who are not candidates for resective surgery,
various thalamic nuclei, including the anterior, centromedian, and pulvinar nuclei, have …