[HTML][HTML] AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation
M Entezari, D Hashemi, A Taheriazam… - Biomedicine & …, 2022 - Elsevier
Diabetes mellitus (DM) is considered as a main challenge in both developing and
developed countries, as lifestyle has changed and its management seems to be vital. Type I …
developed countries, as lifestyle has changed and its management seems to be vital. Type I …
[HTML][HTML] Targeting PI3K/AKT signaling pathway in obesity
MS Savova, LV Mihaylova, D Tews, M Wabitsch… - Biomedicine & …, 2023 - Elsevier
Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …
and intensifies societal health care costs. The development of safe and innovative …
Extensive summary of the important roles of indole propionic acid, a gut microbial metabolite in host health and disease
H Jiang, C Chen, J Gao - Nutrients, 2022 - mdpi.com
Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …
Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective …
K Ramasubbu, V Devi Rajeswari - Molecular and Cellular Biochemistry, 2023 - Springer
Insulin resistance is common in type 2 diabetes mellitus (T2DM), neurodegenerative
diseases, cardiovascular diseases, kidney diseases, and polycystic ovary syndrome …
diseases, cardiovascular diseases, kidney diseases, and polycystic ovary syndrome …
[HTML][HTML] Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis
Y Zhang, Q Wu, J Liu, Z Zhang, X Ma, Y Zhang… - Biomedicine & …, 2022 - Elsevier
Insulin resistance is a characteristic feature of type 2 diabetes. Sulforaphane (SFN) is a
natural antioxidant extracted from the cruciferous vegetables. Recent study reported that …
natural antioxidant extracted from the cruciferous vegetables. Recent study reported that …
[HTML][HTML] Advancing targeted protein degradation for metabolic diseases therapy
QQ Zhou, HT Xiao, F Yang, YD Wang, P Li… - Pharmacological …, 2023 - Elsevier
The development and application of traditional drugs represented by small molecule
chemical drugs and biological agents, especially inhibitors, have become the mainstream …
chemical drugs and biological agents, especially inhibitors, have become the mainstream …
[HTML][HTML] Natural products in non-alcoholic fatty liver disease (NAFLD): Novel lead discovery for drug development
L Wang, Y Yan, L Wu, J Peng - Pharmacological Research, 2023 - Elsevier
With changing lifestyles, non-alcoholic fatty liver disease (NAFLD) has become the most
prevalent liver disease worldwide. A substantial increase in the incidence, mortality, and …
prevalent liver disease worldwide. A substantial increase in the incidence, mortality, and …
NOX as a therapeutic target in liver disease
D Matuz-Mares, H Vázquez-Meza… - Antioxidants, 2022 - mdpi.com
The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or
NOX) plays a critical role in the inflammatory response and fibrosis in several organs such …
NOX) plays a critical role in the inflammatory response and fibrosis in several organs such …
Exploring the therapeutic potential of phytochemicals in Alzheimer's disease: Focus on polyphenols and monoterpenes
I Piccialli, V Tedeschi, L Caputo, S D'Errico… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a chronic, complex neurodegenerative disorder mainly
characterized by the irreversible loss of memory and cognitive functions. Different …
characterized by the irreversible loss of memory and cognitive functions. Different …
Structure and hypoglycemic effect of a neutral polysaccharide isolated from sea cucumber Stichopus japonicus
PX Gong, YC Wu, Y Liu, SZ Lv, Y You, ZL Zhou… - International Journal of …, 2022 - Elsevier
In addition to its high nutritious value, sea cucumber has been recognized by folk medicine
for a long time. This study investigated the structure and hyperglycemic activity of a neutral …
for a long time. This study investigated the structure and hyperglycemic activity of a neutral …