[HTML][HTML] Pathophysiological molecular mechanisms of obesity: a link between MAFLD and NASH with cardiovascular diseases

J Gutiérrez-Cuevas, A Santos… - International Journal of …, 2021 - mdpi.com
Obesity is now a worldwide epidemic ensuing an increase in comorbidities' prevalence,
such as insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated fatty …

[HTML][HTML] Mechanistic view on the effects of SGLT2 inhibitors on lipid metabolism in diabetic milieu

H Yaribeygi, M Maleki, Ž Reiner… - Journal of Clinical …, 2022 - mdpi.com
Chronic hyperglycemia induces pathophysiologic pathways with negative effects on the
metabolism of most substrates as well as lipids and lipoproteins, and thereby induces …

[HTML][HTML] Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis

Y Tang, LJ Yang, H Liu, YJ Song, QQ Yang, Y Liu… - Cell reports, 2023 - cell.com
Obesity, particularly increased visceral fat, positively correlates with various metabolic
challenges, including atherosclerosis, but the mechanism is not fully understood. The aim of …

[HTML][HTML] Intermittent fasting improves high-fat diet-induced obesity cardiomyopathy via alleviating lipid deposition and apoptosis and decreasing m6A methylation in …

Z Xu, Y Qin, B Lv, Z Tian, B Zhang - Nutrients, 2022 - mdpi.com
Intermittent fasting (IF) plays an essential role in improving lipid metabolism disorders
caused by metabolic cardiomyopathy. Growing evidence revealed that N6-methyladenosine …

[HTML][HTML] Adipose tissue-derived mesenchymal stromal/stem cells, obesity and the tumor microenvironment of breast cancer

A Ritter, NN Kreis, SC Hoock, C Solbach, F Louwen… - Cancers, 2022 - mdpi.com
Simple Summary Adipose tissue is the major microenvironment of breast cancer. Adipose
tissue-derived mesenchymal stromal/stem cells (ASCs/MSCs) are key players in adipose …

Danggui Shaoyao San: Chemical characterization and inhibition of oxidative stress and inflammation to treat CCl4-induced hepatic fibrosis

Y Zhao, M Zhao, Z Wang, C Zhao, Y Zhang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Danggui Shaoyao San (DSS) has effective in
treating hepatic ascites and liver disease. Aim of the study To explore the chemical …

[HTML][HTML] Exploring the complex relationship between diabetes and cardiovascular complications: understanding diabetic cardiomyopathy and promising therapies

N Ghosh, L Chacko, H Bhattacharya, J Vallamkondu… - Biomedicines, 2023 - mdpi.com
Diabetes mellitus (DM) and cardiovascular complications are two unmet medical
emergencies that can occur together. The rising incidence of heart failure in diabetic …

[HTML][HTML] Breastfeeding-related health benefits in children and mothers: vital organs perspective

JC Muro-Valdez, A Meza-Rios, BR Aguilar-Uscanga… - Medicina, 2023 - mdpi.com
Breast milk (BM) is a constantly changing fluid that represents the primary source of nutrition
for newborns. It is widely recognized that breastfeeding provides benefits for both the child …

Extracellular matrix remodelling in obesity and metabolic disorders

V Musale, DH Wasserman, L Kang - Life metabolism, 2023 - academic.oup.com
Obesity causes extracellular matrix (ECM) remodelling which can develop into serious
pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM …

[HTML][HTML] The role of NRF2 in obesity-associated cardiovascular risk factors

J Gutiérrez-Cuevas, M Galicia-Moreno… - Antioxidants, 2022 - mdpi.com
The raising prevalence of obesity is associated with an increased risk for cardiovascular
diseases (CVDs), particularly coronary artery disease (CAD), and heart failure, including …