Non-spherical polymeric nanocarriers for therapeutics: The effect of shape on biological systems and drug delivery properties
P Lagarrigue, F Moncalvo, F Cellesi - Pharmaceutics, 2022 - mdpi.com
This review aims to highlight the importance of particle shape in the design of polymeric
nanocarriers for drug delivery systems, along with their size, surface chemistry, density, and …
nanocarriers for drug delivery systems, along with their size, surface chemistry, density, and …
Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery
Lipid-based nanoparticles (LNPs) have been developed to address the transport and uptake
barriers to enhance the delivery efficiency of plasmid DNA therapeutics. In these systems …
barriers to enhance the delivery efficiency of plasmid DNA therapeutics. In these systems …
Kinetic control in assembly of plasmid DNA/polycation complex nanoparticles
Polyelectrolyte complex (PEC) nanoparticles assembled from plasmid DNA (p DNA) and
polycations such as linear polyethylenimine (l PEI) represent a major nonviral delivery …
polycations such as linear polyethylenimine (l PEI) represent a major nonviral delivery …
Synthesis and application of poly (ethylene glycol)-co-poly (β-amino ester) copolymers for small cell lung cancer gene therapy
The design of polymeric nanoparticles for gene therapy requires engineering of polymer
structure to overcome multiple barriers, including prolonged colloidal stability during …
structure to overcome multiple barriers, including prolonged colloidal stability during …
Evaluation of the analgesic effect of high-cannabidiol-content cannabis extracts in different pain models by using polymeric micelles as vehicles
Y Román-Vargas, JD Porras-Arguello… - Molecules, 2023 - mdpi.com
Currently, cannabis is considered an attractive option for the treatment of various diseases,
including pain management. Thus, developing new analgesics is paramount for improving …
including pain management. Thus, developing new analgesics is paramount for improving …
Diethylaminoethyl-chitosan as an efficient carrier for siRNA delivery: Improving the condensation process and the nanoparticles properties
RHFV de Souza, IP Dalla Picola, Q Shi… - International journal of …, 2018 - Elsevier
Chitosan has been indicated as a promising carrier for the preparation of small interfering
RNA (siRNA) delivery systems due to its remarkable properties. However, its weak …
RNA (siRNA) delivery systems due to its remarkable properties. However, its weak …
Enhancing the performance of PEG-b-PCL copolymers as precursors of micellar vehicles for amphotericin B through its conjugation with cholesterol
Amphotericin B (AmB) is an antifungal drug with a broad spectrum of action. It has few
resistance reports, and it is widely used for treating invasive fungal infections. However, it …
resistance reports, and it is widely used for treating invasive fungal infections. However, it …
In silico study of PEI-PEG-squalene-dsDNA polyplex formation: The delicate role of the PEG length in the binding of PEI to DNA
Biocompatible hydrophilic polyethylene glycol (PEG) is widely used in biomedical
applications, such as drug or gene delivery, tissue engineering or as an antifouling …
applications, such as drug or gene delivery, tissue engineering or as an antifouling …
Polymeric nanoparticles based on tyrosine-modified, low molecular weight polyethylenimines for siRNA delivery
A Ewe, S Noske, M Karimov, A Aigner - Pharmaceutics, 2019 - mdpi.com
A major hurdle for exploring RNA interference (RNAi) in a therapeutic setting is still the issue
of in vivo delivery of small RNA molecules (siRNAs). The chemical modification of …
of in vivo delivery of small RNA molecules (siRNAs). The chemical modification of …
Double click-functionalized siRNA polyplexes for gene silencing in epidermal growth factor receptor-positive tumor cells
Sequence-defined lipo-oligomers generated via solid-phase assisted synthesis have been
developed as siRNA delivery systems for RNA-interference (RNAi) based gene silencing …
developed as siRNA delivery systems for RNA-interference (RNAi) based gene silencing …