The lung is exposed to various pollutants and is the primary site for the onset of various
diseases, including infections, allergies, and cancers. One possible treatment approach for …

Oral nucleic acid therapy for transgene expressions of insulin in vivo is an emerging strategy
in treating type I diabetes (T1D) to address poor patient compliance for daily insulin …

The application of nanotechnologies in formulation has significantly promoted the
development of modern medical and pharmacological science, especially for nanoparticle …

Amphotericin B (AmB) is a broad spectrum of antifungal drug used to treat antifungal
diseases. However, due to the high toxicity of AmB, treated patients may suffer the risk of …

Abstract Effects of poly (ethylene glycol)(PEG) block length on the self-assembly of a series
of pH-sensitive poly (N, N-diethylaminoethyl methacrylate) m-PEG n-poly (N, N …

Nonviral gene delivery vectors are attractive candidates compared to viral ones due to their
lower cytotoxicity and immunogenicity. However, their efficacy still requires improvement …

Cancer is one of the leading causes of death worldwide, and battling cancer has always
been a challenging subject in medical sciences. All over the world, scientists from different …

Guanidinopropyl end-modified poly (ethylene glycol)(Gu-PEG) with the molecular weight of
500, 2000, or 5000 has been synthesized and formed the mono-ion complex (MIC) with …

In the search for enzymatically processed RNA fragments, we found the novel three-way
junction motif. The structure prediction suggested the arrangement of helices at acute angle …

PEGylation strategy has been widely used to enhance colloidal stability of polycation/DNA
nanoparticles (NPs) for gene delivery. To investigate the effect of polyethylene glycol (PEG) …