Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its
ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic …

Critically ill post-surgical, post-trauma and/or septic patients are characterised by severe
inflammation. This immune response consists of both a pro-and an anti-inflammatory …

Neutrophil migration is a coordinated process that is altered at multiple stages during sepsis.
In combination with impaired neutrophil function, these alterations culminate in defective …

Following severe tissue injury, patients are exposed to various danger‐and microbe‐
associated molecular patterns, which provoke a strong activation of the neutrophil defense …

Sepsis is a life-threatening condition caused by a dysregulated host response to infection.
Although our understanding in the pathophysiological features of sepsis has increased …

Severe sepsis and organ failure are still the major causes of postoperative morbidity and
mortality after major hepatobiliary pancreatic surgery. Despite recent progress in …

Neutrophilic granulocytes express Fcγ receptor (FcγR)[cluster of differentiation 64 (CD64)
antigen] only when they are activated. Neutrophil CD64, demonstrated using flow cytometry …

OBJECTIVE: We performed a systematic review and meta-analysis of studies to evaluate the
diagnostic accuracy of expression of CD64 on polymorphonuclear neutrophils (PMN) as a …

BACKGROUND: Neutrophil CD64 expression is widely reported as an efficacious biomarker
to differentiate infected patients from other non-infected patients. This meta-analysis was …

Abstract Introduction Neutrophil CD64 (nCD64) expression appears to be a promising
marker of bacterial infections. The aim of this meta-analysis was to assess the accuracy of …