The degradation of cartilage in the human body is impacted by aging, disease, genetic
predisposition and continued insults resulting from daily activity. The burden of cartilage …

Intervertebral disc (IVD) degeneration has been associated with low back pain, which is a
major musculoskeletal disorder and socio-economic problem that affects as many as 600 …

Authored by experts of international renown, the new edition of The Biomechanics of Back
Pain forms a bridge between the latest research and the effective clinical management of …

The nuclei pulposi of the intervertebral discs (IVDs) contain a mixed population of cell types
at various stages of maturation. This tissue is formed either by or with the help of cells from …

A key early sign of degenerative disc disease (DDD) is the loss of nucleus pulposus (NP)
cells (NPCs). Accordingly, NPC transplantation is a treatment strategy for intervertebral disc …

Hydrogel is a suitable scaffold for the nucleus pulposus (NP) regeneration. However, its
unmatched mechanical properties lead to implant failure in late-stage disc degeneration …

The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion,
and load transmission throughout the spine. Importantly, degeneration of the intervertebral …

Degenerative disc disease (DDD) is a common disease which affects millions of people.
Autograft of the bone marrow derived mesenchymal stem cells (BMSCs) have been shown …

Low back pain is a leading debilitating condition that affects every population worldwide, 1
and can lead to diminished physical function, loss of wages, decreased quality of life, and …

Cell-based regenerative medicine therapies have been proposed for repairing the
degenerated intervertebral disc (a major cause of back pain). However, for this approach to …