Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments …

MicroRNAs (miRNAs) constitute a large class of short RNAs (eg, 20–24 nucleotides in
length), whose main function is to posttranscriptionally regulate the expression of protein …

Purpose: To determine the maximum tolerable dose (MTD), safety, pharmacokinetics,
pharmacodynamics, and preliminary efficacy of lenvatinib in patients with advanced …

Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of
primary liver cancers. In the last decade it has become one of the most frequently occurring …

We determined the expression of epithelial-mesenchymal transition (EMT) indicator
proteins, E-cadherin (E-cad), vimentin (VIM), mucin 1 (MUC1) and S100 calcium-binding …

Introduction: The IGF system controls growth, differentiation, and development at the cellular,
organ and organismal levels. IGF1 receptor (IGF1R) signaling is dysregulated in many …

Abstract Sirtuin 5 (SIRT5) is a member of the NAD+‑dependent class III protein
deacetylases. Although it is known that SIRT5 deacetylates and activates urate oxidase in …

Previous studies have indicated that FoxP1, FoxP2 and FoxP3 play important roles in
hepatocellular carcinoma (HCC). However, the effect of FoxP4 in HCC requires further …

BACKGROUND: Deregulated Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways are
found in hepatocellular carcinoma (HCC). This study aimed to test the inhibitory effects of …

Abstract Deregulated PI3K/AKT/mTOR, Ras/Raf/MAPK, and c-Myc signaling pathways are of
prognostic significance in hepatocellular carcinoma (HCC). Sorafenib, the only drug …