Female breast cancer, ovarian cancer, cervical cancer, and endometrial cancer are the most
common tumors and the most common causes of cancer-related mortality worldwide in …

Ferroptosis, characterized by the accumulation of reactive oxygen species and lipid
peroxides, has emerged as an attractive strategy to reverse drug resistance. Of particular …

Introduction Microtubules play a vital role in cancer therapeutics. They are implicated in
tumorigenesis, thus inhibiting tubulin polymerization in cancer cells, and have now become …

Tumor angiogenesis is closely associated with the metastasis and progression of non–small
cell lung cancer (NSCLC), a highly vascularized solid tumor. However, novel therapeutics …

A hydroxamic acid based microtubule-destabilizing agent (MDA) SKLB-14b was discovered
in this study, which was derived from shortening the linker length of the HDAC6 and …

Background Vascular disrupting agents (VDAs) are known to specifically target preexisting
tumoural vasculature. However, systemic side effects as safety or toxicity issues have been …

Simple Summary ASCT2 is an attractive tumour metabolism target based on its critical role
in cancer cell growth. The potential mechanisms of microtubule protein inhibitor C118P in …

Background The incidence of melanoma rapidly increased in the past decades, and the
clinical treatment of melanoma met huge challenges because of tumor heterogeneity and …

Objective In this study, C118P, a novel vascular disrupting agent (VDA), was evaluated for
its ability in improving the ablative effect of high-intensity focused ultrasound (HIFU) on …

新生血管性疾病累及多系统和多器官, 是以血管新生为特征的一大类疾病, 其中包含肿瘤,
心血管疾病和眼部疾病等. 微管抑制剂是一类通过改变微管状态, 从而抑制新生血管生成及阻断 …