Modifications in the epigenetic landscape have been considered a hallmark of cancer.
Histone deacetylation is one of the crucial epigenetic modulations associated with the …

Materials and Methods: Canine cell lines were treated with various concentrations (2.5, 5,
10, 15, and 20 μM) of atovaquone for 24, 48, and 72 h. Human cell lines were used as a …

Metabolic landscape and sensitivity to apoptosis induction play a crucial role in acute
myeloid leukemia (AML) resistance. Therefore, we investigated the effect of metformin, a …

The concept of drug repurposing is focused on the repositioning of drug molecules that have
already undergone safety trials. There are different strategies for drug repurposing. Network …

Bilastine (BLA), 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo [d] imidazole-2-yl)-piperidin-1-yl)-
ethyl)-phenyl)-2-methylpropanoic acid, is an active antihistamine drug. With the idea of …

Alzheimer's disease (AD) is a complex neurodegenerative condition that is characterized by
the build-up of amyloid-beta plaques and neurofibrillary tangles. While multiple theories …

Cancer represents a significant global health and economic burden due to its high mortality
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …

Management of cancer is challenging due to non-targeting and high side effect issues. Drug
repurposing is an innovative method for employing medications for other disease therapy in …

The present study explored anti-tubercular pyrrole derivatives against cancer targets using
different in silico and in vitro approaches. Initially, nineteen anti-tubercular pyrrolyl …

Background Osteosarcoma is the most frequent malignant bone malignancy and the current
treatments are ineffective. Ivermectin, an anti-protozoal drug, has been shown to have anti …