Background Statins, frequently prescribed medications, work by inhibiting the rate‐limiting
enzyme HMG‐CoA reductase (HMGCR) in the mevalonate pathway to reduce cholesterol …

Medication repurposing is one of the effective strategies in approving drugs for new
therapeutic indications. Clarithromycin is a well-known macrolide antibiotic that is commonly …

Colorectal (CRC) and gastric (GC) cancers remain the top lethal cancers and targeted
therapies in this setting are still very limited. Sialyl Lewis X (SLeX), a cancer-associated …

Cancer is one of the leading causes of death on a global scale. Increased technological
advancements and a better understanding of human neoplastic disease make it possible to …

The present study explored anti-tubercular pyrrole derivatives against cancer targets using
different in silico and in vitro approaches. Initially, nineteen anti-tubercular pyrrolyl …

MTHFR (Methylenetetrahydrofolate reductase) is a pivotal enzyme involved in one-carbon
metabolism, which is critical for the proliferation of cancer cells. In line with this, published …

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Introduction: C 60 fullerene has received great attention as a candidate for biomedical …

The statistical analysis of the different versions of the Atom-Bond Connectivity (ABC)
Descriptors (indices) are used to infer the drug molecular structures that are helpful for …

The immune system, a central player in maintaining homeostasis, emerges as a pivotal
factor in the pathogenesis and progression of two seemingly disparate yet interconnected …

Drug repurposing, exploring new uses for existing drugs, offers significant advantages over
developing new ones. Repurposed drugs have already undergone safety testing, reducing …