Disruption of the MDM2-p53 protein-protein interaction by small-molecule inhibitors has
been highly pursued by many academic laboratories and pharmaceutical companies as a …

Asymmetric catalysis has continued to enable the preparation of optically active natural
products over the past decade. This minireview summarizes progress in the catalytic …

Asymmetric reductive amination (ARA) of a prochiral carbonyl compound with an amine
using a H2/hydrogen surrogate is a concise and operationally simple method for the …

The reactivity of metal‐hydride complexes can be harnessed by the modification of ancillary
ligands. With the aim of improving the hydride‐donor ability of the key Mn− H intermediate …

Amine dehydrogenase-catalyzed reductive amination of prochiral ketones with ammonia is
a promising method for the synthesis of optically pure amines in the pharmaceutical and fine …

Sarpagine alkaloids offer signicant opportunities in drug discovery, yet the efficient total
syntheses and diverse structural modifications of these natural products remain highly …

The efficient asymmetric catalytic synthesis of amines containing more than one stereogenic
center is a current challenge. Here, we present a biocatalytic cascade that combines ene …

An iron-catalyzed strategy for the rapid synthesis of indolo [2, 3-c] quinolines has been
developed. This cascade reaction involving alcohol oxidation, nitro reduction, and oxidative …

The concise, collective, and asymmetric total syntheses of four schizozygane alkaloids,
which feature a “Pan lid”-like hexacyclic core scaffold bearing up to six continuous …

The development of highly active and enantioselective ligands and catalysts for the
asymmetric hydrogenation of ketone has been the goal of synthetic chemists for more than …