[HTML][HTML] Counter-regulatory renin–angiotensin system in cardiovascular disease

M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

Factors leading to high morbidity and mortality of COVID‐19 in patients with type 2 diabetes

A Rajpal, L Rahimi, F Ismail‐Beigi - Journal of diabetes, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is a recent pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel coronavirus. Diabetes …

Outcomes of patients with end-stage kidney disease hospitalized with COVID-19

JH Ng, JS Hirsch, R Wanchoo, M Sachdeva… - Kidney international, 2020 - Elsevier
Given the high risk of infection-related mortality, patients with end-stage kidney disease
(ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of …

[HTML][HTML] Hypertension and related diseases in the era of COVID-19: a report from the Japanese Society of Hypertension Task Force on COVID-19

S Shibata, H Arima, K Asayama, S Hoshide… - Hypertension …, 2020 - nature.com
Abstract Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has affected more than seven million people …

Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis

S Narula, S Yusuf, M Chong, C Ramasundarahettige… - The Lancet, 2020 - thelancet.com
Background Angiotensin-converting enzyme 2 (ACE2) is an endogenous counter-regulator
of the renin–angiotensin hormonal cascade. We assessed whether plasma ACE2 …

[HTML][HTML] Vasculopathy and coagulopathy associated with SARS-CoV-2 infection

N Labo, H Ohnuki, G Tosato - Cells, 2020 - mdpi.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of coronavirus disease 2019 (COVID-19), has resulted in> 500,000 deaths …

[HTML][HTML] Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary …

J Ramchand, SK Patel, PM Srivastava, O Farouque… - PloS one, 2018 - journals.plos.org
Background Angiotensin converting enzyme 2 (ACE2) is an endogenous regulator of the
renin angiotensin system. Increased circulating ACE2 predicts adverse outcomes in patients …

[HTML][HTML] ACE and ACE2 in kidney disease

S Mizuiri, Y Ohashi - World journal of nephrology, 2015 - ncbi.nlm.nih.gov
Renin angiotensin system (RAS) activation has a significant influence on renal disease
progression. The classical angiotensin-converting enzyme (ACE)-angiotensin II (Ang II)-Ang …

ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19

K Yamamoto, H Takeshita, H Rakugi - Clinical Science, 2020 - portlandpress.com
Abstract Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane
protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin …

[HTML][HTML] ACE2 Shedding and the Role in COVID-19

J Wang, H Zhao, Y An - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Angiotensin converting enzyme 2 (ACE2), a transmembrane glycoprotein, is an important
part of the renin-angiotensin system (RAS). In the COVID-19 epidemic, it was found to be the …