Progesterone is a steroid hormone traditionally linked with female fertility and pregnancy. In
current reproductive medicine, progesterone and its analogues play crucial roles. While the …

Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Postpartum depression is one of the most common complications of childbirth. Untreated
postpartum depression can have substantial adverse effects on the well-being of the mother …

Three members of the progestin and adipoQ receptor (PAQR) family, PAQR-7, PAQR-8, and
PAQR-5 [membrane progesterone (P4) receptor (PR)(mPR) α, mPRβ, and mPRγ], function …

Analytical advancements, especially methods using gas or liquid chromatography tandem
mass spectrometry, have allowed more specific and reliable measurement of multiple …

Premenstrual dysphoric disorder (PMDD) afflicts 3%‐5% of women of childbearing age, and
is characterised by recurrent negative mood symptoms (eg, irritability, depression, anxiety …

Neuroactive steroids (NAS) are allosteric modulators of the γ-aminobutyric acid (GABA)
system. NAS and GABA are implicated in depression. The peripartum period involves …

Rationale Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABA A
receptors (GABA A Rs) to potentiate the effects of GABA on these receptors. Neurosteroids …

In this review we focused on steroid metabolomics in human fetuses and newborns and its
role in the physiology and pathophysiology of human pregnancy and subsequent stages of …

Many studies have suggested a relationship between stress, sex steroids, and negative
mental and mood changes in humans. The progesterone metabolite allopregnanolone is a …